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A0R079

- GLNA1_MYCS2

UniProt

A0R079 - GLNA1_MYCS2

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Protein

Glutamine synthetase 1

Gene

glnA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4289-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase 1 (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Synonyms:glnA1
Ordered Locus Names:MSMEG_4290, MSMEI_4189
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Glutamine synthetase 1PRO_0000396819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki14 – 14Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_4290.

Structurei

3D structure databases

ProteinModelPortaliA0R079.
SMRiA0R079. Positions 3-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiSCRIPYV.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R079-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEKTSDDIF KLIKDENVEY VDIRFCDLPG VVQHFSIPAS AFDESVFEDG
60 70 80 90 100
LAFDGSSVRG FQSIHESDMM LLPDPNTARI DPFRAAKTLN MNFFVHDPFT
110 120 130 140 150
REAYSRDPRN VARKAENYLA STGIADTAFF GAEAEFYIFD SVSFDSKING
160 170 180 190 200
TFYEVDSESG WWNTGEPFES DGSANRGYKV RPKGGYFPVA PYDHYVDLRD
210 220 230 240 250
QMATNLQNAG FTLERGHHEV GTAGQAEINY KFNTLLAAAD DVLLFKYIIK
260 270 280 290 300
NTAWQAGKTV TFMPKPLFGD NGSGMHAHQS LWKDGQPLFH DESGYAGLSD
310 320 330 340 350
IARHYIGGIL HHAPSLLAFT NPTVNSYKRL VPGYEAPINL VYSQRNRSAC
360 370 380 390 400
VRIPITGNNP KAKRLEFRCP DSSGNPYLAF AAMLMAGIDG IKKKIEPLQP
410 420 430 440 450
VDKDLYELPP DEAAAIPQAP TSLSAVIDKL EEDHEYLTEG GVFTEDLIET
460 470
WISYKRENEI MPIQIRPHPY EFSLYYDV
Length:478
Mass (Da):53,592
Last modified:January 9, 2007 - v1
Checksum:i458E96C6F47A5466
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70139.1.
CP001663 Genomic DNA. Translation: AFP40646.1.
RefSeqiYP_006568941.1. NC_018289.1.
YP_888567.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70139; ABK70139; MSMEG_4290.
AFP40646; AFP40646; MSMEI_4189.
GeneIDi4532067.
KEGGimsg:MSMEI_4189.
msm:MSMEG_4290.
PATRICi18080937. VBIMycSme59918_4210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70139.1 .
CP001663 Genomic DNA. Translation: AFP40646.1 .
RefSeqi YP_006568941.1. NC_018289.1.
YP_888567.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R079.
SMRi A0R079. Positions 3-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_4290.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK70139 ; ABK70139 ; MSMEG_4290 .
AFP40646 ; AFP40646 ; MSMEI_4189 .
GeneIDi 4532067.
KEGGi msg:MSMEI_4189.
msm:MSMEG_4290.
PATRICi 18080937. VBIMycSme59918_4210.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
KOi K01915.
OMAi SCRIPYV.
OrthoDBi EOG6B360N.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-4289-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. Cited for: PUPYLATION AT LYS-14, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiGLNA1_MYCS2
AccessioniPrimary (citable) accession number: A0R079
Secondary accession number(s): I7GBS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3