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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi126 – 132ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-4216-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:MSMEG_4229, MSMEI_4129
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003014391 – 493UDP-N-acetylmuramoylalanine--D-glutamate ligaseAdd BLAST493

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4229

Structurei

3D structure databases

ProteinModelPortaliA0R018
SMRiA0R018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMZ Bacteria
COG0771 LUCA
HOGENOMiHOG000049429
KOiK01925
OMAiVDKGNDY
OrthoDBiPOG091H002Z

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 2 hits
HAMAPiMF_00639 MurD, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR005762 UDP-N-AcMur-Glu_ligase
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 2 hits
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01087 murD, 1 hit

Sequencei

Sequence statusi: Complete.

A0R018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVTGDLAP LTPGARVLVT GAGITGRAVL GALAPLEVAA TLCDDNADAL
60 70 80 90 100
AALAAKGVAV IAPGDAIASI GDYALVVTSP GFAPSAPVLA AAAAAGVPIW
110 120 130 140 150
GDVELAWRLD AAGRYGPPRR WLVVTGTNGK TTTTSMLHDM LVAGGRRSVL
160 170 180 190 200
CGNIGDPVLA VLDQPAELLA VELSSFQLHW APSLRPEAGV VLNVAEDHLD
210 220 230 240 250
WHGSMAAYAR DKARVLDGRV AVVGLDDPVA AGLLPTAAAT VRVGFRLGDP
260 270 280 290 300
AAGELGVRDG KLIDRAFDDG VELADCADIG VAGPIGVLDA LGAAALARAV
310 320 330 340 350
GVAPGAIGAA LASFQVGRHR AEVVGTVDGV VFIDDSKATN PHAAQASITA
360 370 380 390 400
YDRVVWVAGG LLKGASVDEL VRQVANRLAG AVLIGRDRQM VADALSRHAP
410 420 430 440 450
DVPVVELVAG EDSGVLGTNE SIESVGDHVT RVIEVGGRPV SDAVMSAVVS
460 470 480 490
AARDLASPGD TVLLAPAGAS FDQFSGYGQR GDAFAAAVRA AVG
Length:493
Mass (Da):49,558
Last modified:January 9, 2007 - v1
Checksum:i88CEA23CC554E771
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72327.1
CP001663 Genomic DNA Translation: AFP40586.1
RefSeqiWP_011729658.1, NZ_CP009494.1
YP_888506.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK72327; ABK72327; MSMEG_4229
AFP40586; AFP40586; MSMEI_4129
GeneIDi4531703
KEGGimsb:LJ00_20965
msg:MSMEI_4129
msm:MSMEG_4229
PATRICifig|246196.19.peg.4149

Similar proteinsi

Entry informationi

Entry nameiMURD_MYCS2
AccessioniPrimary (citable) accession number: A0R018
Secondary accession number(s): I7GBM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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