A0QZX2 (HIS2_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase
Short name=PRA-PH
EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	MSMEG_4181

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	93 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 93	93	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_1000063356

Sequences

	Sequence		Length	Mass (Da)
	A0QZX2 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 2877D13258B12873	FASTA	93	10,222
	10 20 30 40 50 60 MKQFMLVKTF DALFAELSDK ARTRPAGSGT VAALDAGVHG IGKKILEEAG EVWLAAEHEG 70 80 90 DEALAEEISQ LLYWTQVLMV SRGLTLDDVY RKL

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK75392.1.
RefSeq	YP_888460.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0QZX2.
SMR	A0QZX2. Positions 7-93.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QZX2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000043985; EBMYCP00000042322; EBMYCG00000043980.
GeneID	4531059.
GenomeReviews	Gene locus MSMEG_4181 in contig CP000480_GR.
KEGG	msm:MSMEG_4181.
NMPDR	fig|246196.1.peg.4186.
PATRIC	18080719. VBIMycSme59918_4102.
TIGR	MSMEG_4181.
Phylogenomic databases
eggNOG	COG0140.
GeneTree	EBGT00050000017721.
HOGENOM	HBG646527.
OMA	VWMAAEY.
ProtClustDB	PRK00400.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_4181-MONOMER.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. [Graphical view]
KO	K01523.
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_MYCS2

Accession

Primary (citable) accession number: A0QZX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program