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A0QZU1 (ACDH1_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Ordered Locus Names:MSMEG_4149, MSMEI_4051
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP]
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657
PRO_0000387680

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding159 – 1679NAD By similarity

Sites

Active site1281Acyl-thioester intermediate By similarity
Binding site2871NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QZU1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 0D4A0DD8173B86A9

FASTA31132,978
        10         20         30         40         50         60 
MDKVKVAIIG SGNIGTDLMM KTLRSSSLEM AVLVGVDPRS DGLARAERLG IATTSGGLDH 

        70         80         90        100        110        120 
FVTTPEFEDV AIVFDATSAA AHERHASILA QLNKQVVDLT PAAVGPYVIP TVNMDRVVGE 

       130        140        150        160        170        180 
PNVNMVTCGG QATVPIVAAI SGVTPVHYAE IVASIASRSA GPGTRANIDE FTETTALALE 

       190        200        210        220        230        240 
SVGGATQGKA IIVLNPAEPP LIMRDTVLCL CDEADETEIE AAVERMVASV AEFVPGYRLK 

       250        260        270        280        290        300 
QKVQFQRYTR NSPLRLPEQE ADFTGLQVSV FLEVEGAAHY LPAYAGNLDI MTSAALRTAE 

       310 
RMTELDAIRG K 

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[2]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[3]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK75382.1.
CP001663 Genomic DNA. Translation: AFP40509.1.
RefSeqYP_006568804.1. NC_018289.1.
YP_888429.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0QZU1.
SMRA0QZU1. Positions 3-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_4149.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK75382; ABK75382; MSMEG_4149.
AFP40509; AFP40509; MSMEI_4051.
GeneID13430567.
4533316.
KEGGmsg:MSMEI_4051.
msm:MSMEG_4149.
PATRIC18080661. VBIMycSme59918_4073.

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMATSAGAHR.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-4148-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_MYCS2
AccessionPrimary (citable) accession number: A0QZU1
Secondary accession number(s): I7GCY5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families