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Protein

Argininosuccinate lyase

Gene

argH

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:MSMEG_3769, MSMEI_3680
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000005061 – 469Argininosuccinate lyaseAdd BLAST469

Proteomic databases

PRIDEiA0QYS5

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_3769

Structurei

3D structure databases

ProteinModelPortaliA0QYS5
SMRiA0QYS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A0QYS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNEGSLWG GRFADGPSDA LAALSKSTHF DWALAPYDIK ASKAHARVLH
60 70 80 90 100
RAGLLTDEQR DGLLAGLDSL GSDVADGSFE PLPTDEDVHG ALERGLIDRV
110 120 130 140 150
GPDLGGRLRA GRSRNDQVAT LFRMWLRDAV RRVADGCLEV VNALAVQAAA
160 170 180 190 200
HPTAIMPGKT HLQAAQPILL AHHLLAHAHP LLRDVDRLAD FDDRTAVSPY
210 220 230 240 250
GSGALAGSSL GLDPDAIAED LGFASAADNS VDATASRDFA AEAAFVFAQI
260 270 280 290 300
GVDLSRLAED IILWSSTEFG YVTLHDAWST GSSIMPQKKN PDIAELARGK
310 320 330 340 350
SGRLIGNLTG LLATLKAQPL AYNRDLQEDK EPVFDSVAQL ELLLPAMAGL
360 370 380 390 400
VGTLTFDEER MAELAPAGYT LATDIAEWLV RQGVPFRIAH EAAGAAVKVA
410 420 430 440 450
EGRGVGLDAL TDDEFASINP ALTPDVREVL TVEGSVNARN ARGGTAPTQV
460
AKQLGVVRKA MEELRIRLS
Length:469
Mass (Da):49,744
Last modified:January 9, 2007 - v1
Checksum:iD151C60E839A0C79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73307.1
CP001663 Genomic DNA Translation: AFP40139.1
RefSeqiWP_011729312.1, NZ_CP009494.1
YP_888063.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK73307; ABK73307; MSMEG_3769
AFP40139; AFP40139; MSMEI_3680
GeneIDi4533483
KEGGimsb:LJ00_18725
msg:MSMEI_3680
msm:MSMEG_3769
PATRICifig|246196.19.peg.3708

Similar proteinsi

Entry informationi

Entry nameiARLY_MYCS2
AccessioniPrimary (citable) accession number: A0QYS5
Secondary accession number(s): I7GC35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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