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Protein

Catalase-peroxidase 3

Gene

katG3

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei103Transition state stabilizerUniRule annotation1
Active sitei107Proton acceptorUniRule annotation1
Metal bindingi269Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 3UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 3UniRule annotation
Alternative name(s):
Peroxidase/catalase 3UniRule annotation
Gene namesi
Name:katG3UniRule annotation
Synonyms:katG
Ordered Locus Names:MSMEG_3729, MSMEI_3640
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548401 – 744Catalase-peroxidase 3Add BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki106 ↔ 228Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-254)UniRule annotation
Cross-linki228 ↔ 254Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-106)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_3729.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QYP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPESPDAYVN RTYDQTVAVR RSLKRRNSPA ASEDGLGWPR RLNLRILAQP
60 70 80 90 100
CRTSSPLGED FDYAKEFLSL DLDELARDID EVLTTSQDWW PADFGHYGPL
110 120 130 140 150
VLRMAWHFAG TYRIGDGRGG AGAGMLRFAP LNSFPDNRNL DKARRLLWPV
160 170 180 190 200
KKKYGRKISW SDLMIFAGNR ALESMGCRTF GFAGGREDAW EADETYWGPE
210 220 230 240 250
STWLADERHS GVRDLDQPLA ASEMGLIYVD PQGPATLPDP LASARDIRET
260 270 280 290 300
FRRMGMNDEE TVALIAGGHT FGKSHGPTDP SRCLGPEPEG APLEALGLGW
310 320 330 340 350
VNSFGTGNGA DTVTSGLDGI WTATPTKWDM SFLTTLFAYE WDVALSPAGM
360 370 380 390 400
WQWVPRNGAG AGTVPDPYDP SRTHAPTMLT TDLALQEDPR YRVIALRFLE
410 420 430 440 450
NPDEFADTFA RAWFKLTHID MGPIQRYLGP LVPTERMIWQ DPVPHVDHEL
460 470 480 490 500
ADADDVAALK REILGSGLSV SQLVTTAWAS ASTFRNSDKR GGANGARIRL
510 520 530 540 550
EPQRSWAVNE PEKLAIVLDR LERIRRRFND SHRGGKQISA ADLIMLGGCA
560 570 580 590 600
AVEHAAAEAG HPIEVPCRLG RTDAPQEWTD IEWFSALEPT ADAFRNYVGE
610 620 630 640 650
GNRPPPEHLL VDRASQLTLT APQMTVLLGG LRVLGANHGG SPLGVFTASP
660 670 680 690 700
GALSNDFFVN LLDVNIEWTP RADTADWTAA YEGRDRRTGE VTWIASRVDL
710 720 730 740
SFASDPVLRA ISEVYASADA EEKFVRDFVS AWDKVMNLDL FDRT
Length:744
Mass (Da):82,295
Last modified:November 25, 2008 - v2
Checksum:iA980D38FD8FCBF8E
GO

Sequence cautioni

The sequence ABK74103 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AFP40103 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74103.1. Different initiation.
CP001663 Genomic DNA. Translation: AFP40103.1. Different initiation.
RefSeqiWP_011729291.1. NC_008596.1.
YP_888029.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74103; ABK74103; MSMEG_3729.
AFP40103; AFP40103; MSMEI_3640.
GeneIDi4536221.
KEGGimsg:MSMEI_3640.
msm:MSMEG_3729.
PATRICi18079853. VBIMycSme59918_3673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74103.1. Different initiation.
CP001663 Genomic DNA. Translation: AFP40103.1. Different initiation.
RefSeqiWP_011729291.1. NC_008596.1.
YP_888029.1. NC_008596.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_3729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74103; ABK74103; MSMEG_3729.
AFP40103; AFP40103; MSMEI_3640.
GeneIDi4536221.
KEGGimsg:MSMEI_3640.
msm:MSMEG_3729.
PATRICi18079853. VBIMycSme59918_3673.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG3_MYCS2
AccessioniPrimary (citable) accession number: A0QYP1
Secondary accession number(s): I7FN10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.