ID   A0QYJ2_MYCS2            Unreviewed;       493 AA.
AC   A0QYJ2;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=MSMEG_3677 {ECO:0000313|EMBL:ABK75725.1};
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK75725.1, ECO:0000313|Proteomes:UP000000757};
RN   [1] {ECO:0000313|EMBL:ABK75725.1, ECO:0000313|Proteomes:UP000000757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR   EMBL; CP000480; ABK75725.1; -; Genomic_DNA.
DR   RefSeq; WP_011729255.1; NZ_SIJM01000008.1.
DR   RefSeq; YP_887980.1; NC_008596.1.
DR   AlphaFoldDB; A0QYJ2; -.
DR   SMR; A0QYJ2; -.
DR   STRING; 246196.MSMEG_3677; -.
DR   PaxDb; 246196-MSMEI_3590; -.
DR   GeneID; 66735059; -.
DR   KEGG; msm:MSMEG_3677; -.
DR   PATRIC; fig|246196.19.peg.3625; -.
DR   eggNOG; COG0515; Bacteria.
DR   OrthoDB; 5622056at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:ABK75725.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:ABK75725.1};
KW   Transferase {ECO:0000313|EMBL:ABK75725.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..279
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          335..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   493 AA;  51782 MW;  8E928BE8D5BBEB98 CRC64;
     MPLAAGETFA GYNIIRLLGS GGMGEVYLAA HPRLPRQDAL KVLPTSISAD PEYRERFNRE
     ADVAAALWHP HIVEIHDRGE HDGQLWIAMD YVDGTDAARL LKEQYSGGMP PHQVCEIVTA
     MAGALDYAHQ RGLLHRDVKP ANILLGHPGT DDQRIMLADF GIARYADEAS GLTATNMTVG
     TVTYAAPEQL LGNHLDGRAD QYALAATAYQ LLTGRTPFEH SNPAVVISQH LSAAPPAVGT
     HRPDLATLDP VFAKALAKDP RDRYARCADF ARALRHRLGT DADVADPDAT RLAPVARHAA
     PHKRPKTAAL IAGVLGVLLV AAIVVAAVEF RRADDERPVA RASGAATTTS HTTTPVTTAP
     ASPPPEVTDT VTITDTATDT AAVDTSTPAT TTAATTAAAA AAQTAVIGAS CSPVGATATT
     SDGSTAYCST LATTGASIWS LTQGTIPSPT VTPAATDEPL PFAEESPVRV CMQQTGMTRR
     ECREAIRRSN GLP
//