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Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-3648-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H proteinUniRule annotation
Gene namesi
Name:gcvHUniRule annotation
Ordered Locus Names:MSMEG_3648, MSMEI_3562
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Glycine cleavage system H proteinPRO_0000302393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651N6-lipoyllysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_3648.

Structurei

3D structure databases

ProteinModelPortaliA0QYG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10683Lipoyl-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiENOG4105KE9. Bacteria.
COG0509. LUCA.
HOGENOMiHOG000239392.
KOiK02437.
OMAiNAKFINQ.
OrthoDBiPOG091H04TZ.

Family and domain databases

HAMAPiMF_00272. GcvH. 1 hit.
InterProiIPR000089. Biotin_lipoyl.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiPF01597. GCV_H. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QYG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEIPADLYY TSEHEWVLRT GDDTVRVGIT DYAQSALGDV VFVQLPDVGA
60 70 80 90 100
DVASGDAFGE VESTKSVSDL YAPVTAKVVA VNGDLEGSPE LVNSDPYGEG
110 120 130
WLVDLRVEAG TLDEALGGLL DAEGYRAVVT E
Length:131
Mass (Da):13,840
Last modified:January 9, 2007 - v1
Checksum:iCC5F5E283ECCE9B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69914.1.
CP001663 Genomic DNA. Translation: AFP40025.1.
RefSeqiWP_003895104.1. NZ_CP009494.1.
YP_887951.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK69914; ABK69914; MSMEG_3648.
AFP40025; AFP40025; MSMEI_3562.
GeneIDi4534014.
KEGGimsb:LJ00_18140.
msg:MSMEI_3562.
msm:MSMEG_3648.
PATRICi18079699. VBIMycSme59918_3596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69914.1.
CP001663 Genomic DNA. Translation: AFP40025.1.
RefSeqiWP_003895104.1. NZ_CP009494.1.
YP_887951.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QYG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_3648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK69914; ABK69914; MSMEG_3648.
AFP40025; AFP40025; MSMEI_3562.
GeneIDi4534014.
KEGGimsb:LJ00_18140.
msg:MSMEI_3562.
msm:MSMEG_3648.
PATRICi18079699. VBIMycSme59918_3596.

Phylogenomic databases

eggNOGiENOG4105KE9. Bacteria.
COG0509. LUCA.
HOGENOMiHOG000239392.
KOiK02437.
OMAiNAKFINQ.
OrthoDBiPOG091H04TZ.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-3648-MONOMER.

Family and domain databases

HAMAPiMF_00272. GcvH. 1 hit.
InterProiIPR000089. Biotin_lipoyl.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiPF01597. GCV_H. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCSH_MYCS2
AccessioniPrimary (citable) accession number: A0QYG3
Secondary accession number(s): I7FEX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.