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Protein

Glycogen accumulation regulator GarA

Gene

garA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd and Gdh.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen accumulation regulator GarA
Gene namesi
Name:garA
Ordered Locus Names:MSMEG_3647, MSMEI_3561
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004195341 – 158Glycogen accumulation regulator GarAAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Phosphothreonine; by PknG1 Publication1
Modified residuei21Phosphothreonine; by PknBBy similarity1

Post-translational modificationi

Phosphorylated on Thr-21 by PknB (By similarity). Phosphorylated on Thr-20 by PknG. Phosphorylation at either Thr-20 or Thr-21 prevents binding to target enzymes.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA0QYG2

PTM databases

iPTMnetiA0QYG2

Interactioni

Subunit structurei

Monomer (By similarity). Binds via its FHA domain to Kgd, Gdh, and the N-terminal region of PknG.By similarity

Protein-protein interaction databases

IntActiA0QYG2, 3 interactors
STRINGi246196.MSMEG_3647

Structurei

3D structure databases

ProteinModelPortaliA0QYG2
SMRiA0QYG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 125FHAPROSITE-ProRule annotationAdd BLAST50

Phylogenomic databases

eggNOGiENOG4108UW8 Bacteria
COG1716 LUCA
HOGENOMiHOG000242873
OrthoDBiPOG091H09TV

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0QYG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKDSNLGA DQSEDVTVET TSVFRADFLN ELDAPAAAGT EGAVSGVEGL
60 70 80 90 100
PSGSALLVVK RGPNAGSRFL LDQPTTSAGR HPDSDIFLDD VTVSRRHAEF
110 120 130 140 150
RLEGGEFQVV DVGSLNGTYV NREPVDSAVL ANGDEVQIGK FRLVFLTGPK

SDDSGSNA
Length:158
Mass (Da):16,584
Last modified:October 3, 2012 - v2
Checksum:i884B68B7C37084BE
GO

Sequence cautioni

The sequence ABK73997 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73997.1 Different initiation.
CP001663 Genomic DNA Translation: AFP40024.1
RefSeqiYP_887950.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK73997; ABK73997; MSMEG_3647
AFP40024; AFP40024; MSMEI_3561
GeneIDi4536307
KEGGimsb:LJ00_18135
msg:MSMEI_3561
msm:MSMEG_3647
PATRICifig|246196.19.peg.3595

Similar proteinsi

Entry informationi

Entry nameiGARA_MYCS2
AccessioniPrimary (citable) accession number: A0QYG2
Secondary accession number(s): I7GBT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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