Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycogen accumulation regulator GarA

Gene

garA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd and Gdh.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen accumulation regulator GarA
Gene namesi
Name:garA
Ordered Locus Names:MSMEG_3647, MSMEI_3561
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004195341 – 158Glycogen accumulation regulator GarAAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Phosphothreonine; by PknG1 Publication1
Modified residuei21Phosphothreonine; by PknBBy similarity1

Post-translational modificationi

Phosphorylated on Thr-21 by PknB (By similarity). Phosphorylated on Thr-20 by PknG. Phosphorylation at either Thr-20 or Thr-21 prevents binding to target enzymes.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiA0QYG2.

Interactioni

Subunit structurei

Monomer (By similarity). Binds via its FHA domain to Kgd, Gdh, and the N-terminal region of PknG.By similarity

Protein-protein interaction databases

IntActiA0QYG2. 3 interactors.
STRINGi246196.MSMEG_3647.

Structurei

3D structure databases

ProteinModelPortaliA0QYG2.
SMRiA0QYG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 125FHAPROSITE-ProRule annotationAdd BLAST50

Phylogenomic databases

eggNOGiENOG4108UW8. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000242873.
OrthoDBiPOG091H09TV.

Family and domain databases

InterProiView protein in InterPro
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
PfamiView protein in Pfam
PF00498. FHA. 1 hit.
SMARTiView protein in SMART
SM00240. FHA. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiView protein in PROSITE
PS50006. FHA_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QYG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKDSNLGA DQSEDVTVET TSVFRADFLN ELDAPAAAGT EGAVSGVEGL
60 70 80 90 100
PSGSALLVVK RGPNAGSRFL LDQPTTSAGR HPDSDIFLDD VTVSRRHAEF
110 120 130 140 150
RLEGGEFQVV DVGSLNGTYV NREPVDSAVL ANGDEVQIGK FRLVFLTGPK

SDDSGSNA
Length:158
Mass (Da):16,584
Last modified:October 3, 2012 - v2
Checksum:i884B68B7C37084BE
GO

Sequence cautioni

The sequence ABK73997 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73997.1. Different initiation.
CP001663 Genomic DNA. Translation: AFP40024.1.
RefSeqiYP_887950.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK73997; ABK73997; MSMEG_3647.
AFP40024; AFP40024; MSMEI_3561.
GeneIDi4536307.
KEGGimsb:LJ00_18135.
msg:MSMEI_3561.
msm:MSMEG_3647.
PATRICifig|246196.19.peg.3595.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGARA_MYCS2
AccessioniPrimary (citable) accession number: A0QYG2
Secondary accession number(s): I7GBT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 5, 2017
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome