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A0QYF5 (A0QYF5_MYCS2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate synthase G HAMAP MF_00641
EC=2.3.3.9 HAMAP MF_00641
Gene names
Name:glcB HAMAP MF_00641
Ordered Locus Names:MSMEG_3640
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK71908.1
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length721 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA. HAMAP MF_00641 SAAS SAAS006253

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. HAMAP MF_00641 SAAS SAAS006253

Subunit structure

Monomer By similarity. HAMAP MF_00641 SAAS SAAS006253

Subcellular location

Cytoplasm By similarity HAMAP MF_00641.

Sequence similarities

Belongs to the malate synthase family. GlcB subfamily. HAMAP MF_00641

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3311Proton acceptor By similarity HAMAP MF_00641
Active site6261Proton donor By similarity HAMAP MF_00641

Sequences

Sequence LengthMass (Da)Tools
A0QYF5 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: EB469D38B135483E

FASTA72178,277
        10         20         30         40         50         60 
MAKVLHDFIT NEALPGTGVD PDSFWSGVDK VVSDLTPKNQ ELLARRDELQ AQIDKWHRSH 

        70         80         90        100        110        120 
VLEPVDPVAY KQFLTDIGYL LPEPEDFTIT TAGVDDEITT TAGPQLVVPI LNARFALNAA 

       130        140        150        160        170        180 
NARWGSLYDA LYGTDVISEE DGAEKGTGYN KIRGDKVIAY ARGFLDEVVP LAEGSWSEAT 

       190        200        210        220        230        240 
GLKIDDGALE VALGDDKVTG LSVPEAFVGY TGELGEPQWS VLLRNHGLHI EILIDPSSPV 

       250        260        270        280        290        300 
GSTDSAGIKD VVLESAVTTI MDFEDSVAAV DADDKVLGYR NWLGLNRGDL TEEVTKGDKT 

       310        320        330        340        350        360 
FTRVLNDDRV FKTPDGEGEL TLPGRSLLFV RNVGHLMTND AIVDADGNEI PEGIQDALFT 

       370        380        390        400        410        420 
SLIAMHGLKA GDQNGPLTNS RTGSIYIVKP KMHGPDEVAF TCELFSRVED VLGLPANTLK 

       430        440        450        460        470        480 
VGIMDEERRT SVNLKACIKA AADRVVFINT GFLDRTGDEI HTSMEAGPMV RKGTMKSQPW 

       490        500        510        520        530        540 
ILAYEDANVD VGLAAGFSGK AQIGKGMWAM TDLMADMVEQ KIGQPKAGAT TAWVPSPTAA 

       550        560        570        580        590        600 
TLHAMHYHQV DVFAVQSELA GKKRGKLEDL LTIPLADSSL TWSPEEIHEE VDNNCQSILG 

       610        620        630        640        650        660 
YVVRWIDAGV GCSKVPDIHD VALMEDRATL RISSQLLANW LRHGVITEED VKTSLRRMAA 

       670        680        690        700        710        720 
VVDEQNAGDP AYLPMAPNPD ASIAFAAAQE LILSGTQQPN GYTEPILHRR RREFKARAAA 


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References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK71908.1.
RefSeqYP_887943.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0QYF5.
SMRA0QYF5. Positions 1-719.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QYF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000043341; EBMYCP00000041678; EBMYCG00000043336.
GeneID4537600.
GenomeReviewsGene locus MSMEG_3640 in contig CP000480_GR.
KEGGmsm:MSMEG_3640.
NMPDRfig|246196.1.peg.3646.
PATRIC18079683. VBIMycSme59918_3588.
TIGRMSMEG_3640.

Phylogenomic databases

eggNOGCOG2225.
GeneTreeEBGT00070000032288.
HOGENOMHBG350005.
OMAPKMHGPD.
PhylomeDBA0QYF5.
ProtClustDBPRK02999.

Family and domain databases

HAMAPMF_00641. Malate_synth_G.
[Tree]
InterProIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
Gene3DG3DSA:2.170.170.11. Malate_synth_G_beta_sub_dom. 2 hits.
KOK01638.
PANTHERPTHR21631:SF1. Malate_synthase. 1 hit.
PfamPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMSSF51645. Malat_synth_like. 1 hit.
TIGRFAMsTIGR01345. Malate_syn_G. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0QYF5_MYCS2
AccessionPrimary (citable) accession number: A0QYF5
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info