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A0QYE7 (A0QYE7_MYCS2) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109
EC=1.1.1.44 PIRNR PIRNR000109
Gene names
Name:gnd EMBL ABK74443.1
Ordered Locus Names:MSMEG_3632
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK74443.1
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding20 – 256NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding43 – 453NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding85 – 873NADP By similarity PIRSR PIRSR000109-3
Region139 – 1413Substrate binding By similarity PIRSR PIRSR000109-2
Region196 – 1972Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1931Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2001Proton donor By similarity PIRSR PIRSR000109-1
Binding site1131NADP By similarity PIRSR PIRSR000109-3
Binding site1131Substrate By similarity PIRSR PIRSR000109-2
Binding site2011Substrate By similarity PIRSR PIRSR000109-2
Binding site2711Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2981Substrate By similarity PIRSR PIRSR000109-2
Binding site4561Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4621Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A0QYE7 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 2E8DFD43C98DF329

FASTA48851,812
        10         20         30         40         50         60 
MTASSTPSST TGTAQIGVTG LAVMGSNIAR NFARHGYTVA LHNRSIAKTD ALLAEHGSEG 

        70         80         90        100        110        120 
KFVRSETIAE FIDALEKPRK VLIMVKAGEA TDAVIDELAD AMEPGDIIID GGNALYTDTI 

       130        140        150        160        170        180 
RREAAIRARG LHFVGAGISG GEEGALNGPS IMPGGPAESY ESLGPLLEEI SAHVDGVPCC 

       190        200        210        220        230        240 
THIGPDGAGH FVKMVHNGIE YSDMQLIGEA YQLLRDGLGM SAGEIADVFE EWNRGDLDSF 

       250        260        270        280        290        300 
LVEITAKVLR QTDAKTGKPL VDVIVDEAEQ KGTGRWTVKS ALDLGVPVTG IAEAVFARAL 

       310        320        330        340        350        360 
SGSVPQRKAT VGLASGALGA TPSDAADFIE AVRRALYASK IVAYAQGFNQ IQAGSAEYNW 

       370        380        390        400        410        420 
NLTPGDLATI WRGGCIIRAK FLNRIKDAYD AEPDLPTLLA APYFRDAVEA GIDSWRRVVV 

       430        440        450        460        470        480 
TATQLGIPVP GFASALSYYD ALRTERLPAA LIQGLRDYFG AHTYGRIDAE PGKKFHTLWS 


GDHSEVEA

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK74443.1.
RefSeqYP_887935.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0QYE7.
SMRA0QYE7. Positions 14-480.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QYE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000044161; EBMYCP00000042498; EBMYCG00000044156.
GeneID4531569.
GenomeReviewsGene locus MSMEG_3632 in contig CP000480_GR.
KEGGmsm:MSMEG_3632.
NMPDRfig|246196.1.peg.3638.
PATRIC18079667. VBIMycSme59918_3580.
TIGRMSMEG_3632.

Phylogenomic databases

eggNOGCOG0362.
GeneTreeEBGT00050000015862.
HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBA0QYE7.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0QYE7_MYCS2
AccessionPrimary (citable) accession number: A0QYE7
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info