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Protein

Urease subunit gamma

Gene

ureA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease (MSMEG_1093)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-3627-MONOMER.
UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit gammaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit gammaUniRule annotation
Gene namesi
Name:ureAUniRule annotation
Ordered Locus Names:MSMEG_3627, MSMEI_3542
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Urease subunit gammaPRO_1000046338Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_3627.

Structurei

3D structure databases

ProteinModelPortaliA0QYE2.
SMRiA0QYE2. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease gamma subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YZ9. Bacteria.
COG0831. LUCA.
HOGENOMiHOG000075053.
KOiK01430.
OMAiELMSYGT.
OrthoDBiEOG69PQ9G.

Family and domain databases

Gene3Di3.30.280.10. 1 hit.
HAMAPiMF_00739. Urease_gamma.
InterProiIPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view]
PfamiPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001223. Urease_gamma. 1 hit.
ProDomiPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54111. SSF54111. 1 hit.
TIGRFAMsiTIGR00193. urease_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QYE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTPHEQDR LLISYAAELA RRRRARGLRL NHPEAVAVIT DHLLEGARDG
60 70 80 90 100
RTVAELMVSG RSVLTRDDVM DGVPEMLHDV QVEATFPDGT KLVTVHQPIA
Length:100
Mass (Da):11,160
Last modified:January 9, 2007 - v1
Checksum:i2A75A38F49C77E2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74952.1.
CP001663 Genomic DNA. Translation: AFP40005.1.
RefSeqiWP_011729214.1. NZ_CP009494.1.
YP_887930.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74952; ABK74952; MSMEG_3627.
AFP40005; AFP40005; MSMEI_3542.
GeneIDi4531860.
KEGGimsb:LJ00_18035.
msg:MSMEI_3542.
msm:MSMEG_3627.
PATRICi18079657. VBIMycSme59918_3575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74952.1.
CP001663 Genomic DNA. Translation: AFP40005.1.
RefSeqiWP_011729214.1. NZ_CP009494.1.
YP_887930.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QYE2.
SMRiA0QYE2. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_3627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74952; ABK74952; MSMEG_3627.
AFP40005; AFP40005; MSMEI_3542.
GeneIDi4531860.
KEGGimsb:LJ00_18035.
msg:MSMEI_3542.
msm:MSMEG_3627.
PATRICi18079657. VBIMycSme59918_3575.

Phylogenomic databases

eggNOGiENOG4108YZ9. Bacteria.
COG0831. LUCA.
HOGENOMiHOG000075053.
KOiK01430.
OMAiELMSYGT.
OrthoDBiEOG69PQ9G.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.
BioCyciMSME246196:GJ4Y-3627-MONOMER.

Family and domain databases

Gene3Di3.30.280.10. 1 hit.
HAMAPiMF_00739. Urease_gamma.
InterProiIPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view]
PfamiPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001223. Urease_gamma. 1 hit.
ProDomiPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54111. SSF54111. 1 hit.
TIGRFAMsiTIGR00193. urease_gam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.

Entry informationi

Entry nameiURE3_MYCS2
AccessioniPrimary (citable) accession number: A0QYE2
Secondary accession number(s): I7FEV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.