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Protein

Urease subunit gamma

Gene

ureA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease (MSMEI_1061), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease (MSMEG_1093)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit gammaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit gammaUniRule annotation
Gene namesi
Name:ureAUniRule annotation
Ordered Locus Names:MSMEG_3627, MSMEI_3542
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000463381 – 100Urease subunit gammaAdd BLAST100

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_3627

Structurei

3D structure databases

ProteinModelPortaliA0QYE2
SMRiA0QYE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease gamma subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YZ9 Bacteria
COG0831 LUCA
HOGENOMiHOG000075053
KOiK01430
OMAiMIHEVQV
OrthoDBiPOG091H09TI

Family and domain databases

CDDicd00390 Urease_gamma, 1 hit
Gene3Di3.30.280.10, 1 hit
HAMAPiMF_00739 Urease_gamma, 1 hit
InterProiView protein in InterPro
IPR012010 Urease_gamma
IPR002026 Urease_gamma/gamma-beta_su
IPR036463 Urease_gamma_sf
PANTHERiPTHR45301 PTHR45301, 1 hit
PfamiView protein in Pfam
PF00547 Urease_gamma, 1 hit
PIRSFiPIRSF001223 Urease_gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002319 Urease_gamma_reg, 1 hit
SUPFAMiSSF54111 SSF54111, 1 hit
TIGRFAMsiTIGR00193 urease_gam, 1 hit

Sequencei

Sequence statusi: Complete.

A0QYE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTPHEQDR LLISYAAELA RRRRARGLRL NHPEAVAVIT DHLLEGARDG
60 70 80 90 100
RTVAELMVSG RSVLTRDDVM DGVPEMLHDV QVEATFPDGT KLVTVHQPIA
Length:100
Mass (Da):11,160
Last modified:January 9, 2007 - v1
Checksum:i2A75A38F49C77E2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74952.1
CP001663 Genomic DNA Translation: AFP40005.1
RefSeqiWP_011729214.1, NZ_CP009494.1
YP_887930.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK74952; ABK74952; MSMEG_3627
AFP40005; AFP40005; MSMEI_3542
GeneIDi4531860
KEGGimsb:LJ00_18035
msg:MSMEI_3542
msm:MSMEG_3627
PATRICifig|246196.19.peg.3575

Similar proteinsi

Entry informationi

Entry nameiURE3_MYCS2
AccessioniPrimary (citable) accession number: A0QYE2
Secondary accession number(s): I7FEV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health