A0QX95 (TRPC_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	MSMEG_3219

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 272	271	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018501

Sequences

	Sequence		Length	Mass (Da)
	A0QX95 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 63E81444A7EAF759	FASTA	272	28,370
	10 20 30 40 50 60 MSSATVLDSI IEGVRADVAA REAVISLDEI KERAKAAPPP LNVMAALREP GIGVIAEVKR 70 80 90 100 110 120 ASPSRGALAS IGDPAELAQA YQDGGARVIS VLTEQRRFNG SLDDLDAVRA AVSIPVLRKD 130 140 150 160 170 180 FIVRPYQIHE ARAHGADMLL LIVAALDQPV LESLLERTES LGMTALVEVH TEEEADRALK 190 200 210 220 230 240 AGASVIGVNA RDLKTLEVDR TVFSRIAPGL PSNVIRVAES GVRGTADLLA YAGAGADAVL 250 260 270 VGEGLVTSGD PRSAVADLVT AGTHPSCPKP AR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.
[2]	"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed: 18955433] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK74351.1.
RefSeq	YP_887533.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0QX95.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QX95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000042193; EBMYCP00000040530; EBMYCG00000042188.
GeneID	4535694.
GenomeReviews	Gene locus MSMEG_3219 in contig CP000480_GR.
KEGG	msm:MSMEG_3219.
NMPDR	fig|246196.1.peg.3229.
PATRIC	18078866. VBIMycSme59918_3181.
TIGR	MSMEG_3219.
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000017090.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_3219-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_MYCS2

Accession

Primary (citable) accession number: A0QX95

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program