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A0QWX4

- CAPP_MYCS2

UniProt

A0QWX4 - CAPP_MYCS2

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei161 – 1611UniRule annotation
    Active sitei593 – 5931UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-3097-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotation
    Ordered Locus Names:MSMEG_3097, MSMEI_3019
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 933933Phosphoenolpyruvate carboxylasePRO_1000025566Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_3097.

    Structurei

    3D structure databases

    ProteinModelPortaliA0QWX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2352.
    HOGENOMiHOG000238647.
    KOiK01595.
    OMAiSILNCET.
    OrthoDBiEOG6TJ7T8.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QWX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADSNDTALE PFGSVQRTHI GREASEPMRE DIRLLGAILG DTVREQNGEE    50
    VFDLVERARV ESFRVRRSEI DRSELADMFS GVDAHQAIPV IRAFTHFALL 100
    ANVAEDIHRE RRRAVHVAAG KPPQDSSLAA TYRKLDAADL DVDKVADTLT 150
    GALVSPVITA HPTETRRRTV FDTQHRITEL MRLRLHGHTR TDDNRDIETE 200
    LRRHILTLWQ TALIRLSRLK ISDEIETGLR YYEAAFFDVI PQVNAEVRDA 250
    LRKRWPDAKL LEEPILRPGS WIGGDRDGNP NVTPEVVRHA TGRAAYVALA 300
    HYFEQITALE QELSMSARLV KVTPALAALA DACHEPARAD EPYRRALRVI 350
    HARLTSTARE ILDEQPEHGL DLGLPRYQTP AEFLADLDAV DGSLRANGSR 400
    VLADDRLGRL REAVRVFGFH LSGLDMRQNS DVHEEVVAEL LAWAGVHPDY 450
    TSLSEPQRVE LLAAEIATRR PLIREGAELS ELAQKELGIV AAAARAVKVF 500
    GPQAVPNYII SMCQSVSDML EAAVLLKEAG LLDISGSTPY APVGVVPLFE 550
    TIDDLQRGSS ILEAALDLPE YRTMVDARDG HQEVMLGYSD SNKDGGYLAA 600
    NWALYRAELD LVESARKTGI RLRLFHGRGG TVGRGGGPSY DAILAQPPGA 650
    VKGSLRITEQ GEVIAAKYAE PRIAHRNLET LLAATLEASL LDVEGLGEEA 700
    EPAYQVLDEL AALAQRAYSE LVHETPGFVE YFKTSTPVSE IGALNIGSRP 750
    TSRKPTTSIA DLRAIPWVLA WSQSRVMLPG WYGTGSAFEN WIGTDPDGAR 800
    LRVLQDLYAR WPFFRTVLSN MAQVLAKADM GLAARYSELV EDADLRARVF 850
    DKIVAEHDRT IRMHRLITGQ DDLLADNAAL ARSVFNRFPY LEPLNHLQVE 900
    LLRRYRSGET DELVQRGILL TMSGLATALR NSG 933
    Length:933
    Mass (Da):103,351
    Last modified:January 9, 2007 - v1
    Checksum:i33F2EAC46B98F7D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK70062.1.
    CP001663 Genomic DNA. Translation: AFP39483.1.
    RefSeqiWP_011728811.1. NC_018289.1.
    YP_006567778.1. NC_018289.1.
    YP_887412.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK70062; ABK70062; MSMEG_3097.
    AFP39483; AFP39483; MSMEI_3019.
    GeneIDi4535253.
    KEGGimsg:MSMEI_3019.
    msm:MSMEG_3097.
    PATRICi18078620. VBIMycSme59918_3058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK70062.1 .
    CP001663 Genomic DNA. Translation: AFP39483.1 .
    RefSeqi WP_011728811.1. NC_018289.1.
    YP_006567778.1. NC_018289.1.
    YP_887412.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0QWX4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_3097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK70062 ; ABK70062 ; MSMEG_3097 .
    AFP39483 ; AFP39483 ; MSMEI_3019 .
    GeneIDi 4535253.
    KEGGi msg:MSMEI_3019.
    msm:MSMEG_3097.
    PATRICi 18078620. VBIMycSme59918_3058.

    Phylogenomic databases

    eggNOGi COG2352.
    HOGENOMi HOG000238647.
    KOi K01595.
    OMAi SILNCET.
    OrthoDBi EOG6TJ7T8.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-3097-MONOMER.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], IDENTIFICATION OF N-TERMINUS.
      Strain: ATCC 700084 / mc(2)155.

    Entry informationi

    Entry nameiCAPP_MYCS2
    AccessioniPrimary (citable) accession number: A0QWX4
    Secondary accession number(s): I7FL87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3