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A0QWX4

- CAPP_MYCS2

UniProt

A0QWX4 - CAPP_MYCS2

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Protein

Phosphoenolpyruvate carboxylase

Gene
ppc, MSMEG_3097, MSMEI_3019
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611 By similarity
Active sitei593 – 5931 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-3097-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Ordered Locus Names:MSMEG_3097, MSMEI_3019
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 933933Phosphoenolpyruvate carboxylaseUniRule annotationPRO_1000025566Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_3097.

Structurei

3D structure databases

ProteinModelPortaliA0QWX4.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiSILNCET.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QWX4-1 [UniParc]FASTAAdd to Basket

« Hide

MADSNDTALE PFGSVQRTHI GREASEPMRE DIRLLGAILG DTVREQNGEE    50
VFDLVERARV ESFRVRRSEI DRSELADMFS GVDAHQAIPV IRAFTHFALL 100
ANVAEDIHRE RRRAVHVAAG KPPQDSSLAA TYRKLDAADL DVDKVADTLT 150
GALVSPVITA HPTETRRRTV FDTQHRITEL MRLRLHGHTR TDDNRDIETE 200
LRRHILTLWQ TALIRLSRLK ISDEIETGLR YYEAAFFDVI PQVNAEVRDA 250
LRKRWPDAKL LEEPILRPGS WIGGDRDGNP NVTPEVVRHA TGRAAYVALA 300
HYFEQITALE QELSMSARLV KVTPALAALA DACHEPARAD EPYRRALRVI 350
HARLTSTARE ILDEQPEHGL DLGLPRYQTP AEFLADLDAV DGSLRANGSR 400
VLADDRLGRL REAVRVFGFH LSGLDMRQNS DVHEEVVAEL LAWAGVHPDY 450
TSLSEPQRVE LLAAEIATRR PLIREGAELS ELAQKELGIV AAAARAVKVF 500
GPQAVPNYII SMCQSVSDML EAAVLLKEAG LLDISGSTPY APVGVVPLFE 550
TIDDLQRGSS ILEAALDLPE YRTMVDARDG HQEVMLGYSD SNKDGGYLAA 600
NWALYRAELD LVESARKTGI RLRLFHGRGG TVGRGGGPSY DAILAQPPGA 650
VKGSLRITEQ GEVIAAKYAE PRIAHRNLET LLAATLEASL LDVEGLGEEA 700
EPAYQVLDEL AALAQRAYSE LVHETPGFVE YFKTSTPVSE IGALNIGSRP 750
TSRKPTTSIA DLRAIPWVLA WSQSRVMLPG WYGTGSAFEN WIGTDPDGAR 800
LRVLQDLYAR WPFFRTVLSN MAQVLAKADM GLAARYSELV EDADLRARVF 850
DKIVAEHDRT IRMHRLITGQ DDLLADNAAL ARSVFNRFPY LEPLNHLQVE 900
LLRRYRSGET DELVQRGILL TMSGLATALR NSG 933
Length:933
Mass (Da):103,351
Last modified:January 9, 2007 - v1
Checksum:i33F2EAC46B98F7D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70062.1.
CP001663 Genomic DNA. Translation: AFP39483.1.
RefSeqiWP_011728811.1. NC_018289.1.
YP_006567778.1. NC_018289.1.
YP_887412.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70062; ABK70062; MSMEG_3097.
AFP39483; AFP39483; MSMEI_3019.
GeneIDi4535253.
KEGGimsg:MSMEI_3019.
msm:MSMEG_3097.
PATRICi18078620. VBIMycSme59918_3058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70062.1 .
CP001663 Genomic DNA. Translation: AFP39483.1 .
RefSeqi WP_011728811.1. NC_018289.1.
YP_006567778.1. NC_018289.1.
YP_887412.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0QWX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_3097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK70062 ; ABK70062 ; MSMEG_3097 .
AFP39483 ; AFP39483 ; MSMEI_3019 .
GeneIDi 4535253.
KEGGi msg:MSMEI_3019.
msm:MSMEG_3097.
PATRICi 18078620. VBIMycSme59918_3058.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi SILNCET.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-3097-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], IDENTIFICATION OF N-TERMINUS.
    Strain: ATCC 700084 / mc(2)155.

Entry informationi

Entry nameiCAPP_MYCS2
AccessioniPrimary (citable) accession number: A0QWX4
Secondary accession number(s): I7FL87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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