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Protein

UvrABC system protein C

Gene

uvrC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-3082-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:MSMEG_3078, MSMEI_3000
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000778091 – 706UvrABC system protein CAdd BLAST706

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_3078

Structurei

3D structure databases

ProteinModelPortaliA0QWV6
SMRiA0QWV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 95GIY-YIGUniRule annotationAdd BLAST80
Domaini208 – 243UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279962
KOiK03703
OMAiLFPIRQC
OrthoDBiPOG091H01BS

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

A0QWV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPATYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLTSYFADI
60 70 80 90 100
TSLAPRTRQM VMTAGSVEWT VVTTEVEALQ LEYNWIKEFD PRFNVRYRDD
110 120 130 140 150
KSYPVLAVTL NEEYPRLMVY RGPRRKGVRY FGPYSHAWAI RETLDLLTRV
160 170 180 190 200
FPARTCSAGV FKRHKQIDRP CLLGYIDKCS APCVGRVSAE QHRQIVLDFC
210 220 230 240 250
DFLGGKTDRL AKDMEQQMTA AAEQLDFERA ARLRDDISAL KRALEKQAVV
260 270 280 290 300
FGDGTDADVV AFADDDLEAA VQVFHVRGGR VRGQRGWIVE KSSEPAATGD
310 320 330 340 350
ADLGQSGQEQ LVEQFLTQFY GEQAELGSAS DTGGDEATNP VPRQVLVPVL
360 370 380 390 400
PPNADELATW LSGLRGSRVS LRVPVRGDKR ALAETVQRNA QEALAQHKLK
410 420 430 440 450
RAGDFNARSE ALQSIQEALG LADAPLRIEC VDISHVQGTD VVASLVVFED
460 470 480 490 500
GLPRKSDYRH YAIREAAGDG RSDDVASIAE VTRRRFLRHT SDSQPDPSAE
510 520 530 540 550
QRPRRFAYPP NLFVVDGGAP QVNAAAAVLE DLGVDDVAVI GLAKRLEEVW
560 570 580 590 600
VPSEPDPVIL PRNSEGLYLL QRVRDEAHRF AISYHRSKRS KRMTASALDS
610 620 630 640 650
VRGLGEHRRK ALVAHFGSVA RLKEATVDEI TAVPGIGVAT ARAVQEALGV
660 670 680 690 700
APQNGTAPDP APGTGDPQTP ADPHSAATAA DIEDDRHATG ATGPQMNGSE

QQVDRV
Length:706
Mass (Da):77,443
Last modified:January 9, 2007 - v1
Checksum:i576F941C487F429E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74829.1
CP001663 Genomic DNA Translation: AFP39464.1
RefSeqiWP_011728800.1, NZ_CP009494.1
YP_887394.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK74829; ABK74829; MSMEG_3078
AFP39464; AFP39464; MSMEI_3000
GeneIDi4537665
KEGGimsb:LJ00_15315
msg:MSMEI_3000
msm:MSMEG_3078
PATRICifig|246196.19.peg.3039

Similar proteinsi

Entry informationi

Entry nameiUVRC_MYCS2
AccessioniPrimary (citable) accession number: A0QWV6
Secondary accession number(s): I7GAF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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