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Protein

UvrABC system protein C

Gene

uvrC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:MSMEG_3078, MSMEI_3000
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000778091 – 706UvrABC system protein CAdd BLAST706

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_3078.

Structurei

3D structure databases

ProteinModelPortaliA0QWV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 95GIY-YIGUniRule annotationAdd BLAST80
Domaini208 – 243UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QWV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPATYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLTSYFADI
60 70 80 90 100
TSLAPRTRQM VMTAGSVEWT VVTTEVEALQ LEYNWIKEFD PRFNVRYRDD
110 120 130 140 150
KSYPVLAVTL NEEYPRLMVY RGPRRKGVRY FGPYSHAWAI RETLDLLTRV
160 170 180 190 200
FPARTCSAGV FKRHKQIDRP CLLGYIDKCS APCVGRVSAE QHRQIVLDFC
210 220 230 240 250
DFLGGKTDRL AKDMEQQMTA AAEQLDFERA ARLRDDISAL KRALEKQAVV
260 270 280 290 300
FGDGTDADVV AFADDDLEAA VQVFHVRGGR VRGQRGWIVE KSSEPAATGD
310 320 330 340 350
ADLGQSGQEQ LVEQFLTQFY GEQAELGSAS DTGGDEATNP VPRQVLVPVL
360 370 380 390 400
PPNADELATW LSGLRGSRVS LRVPVRGDKR ALAETVQRNA QEALAQHKLK
410 420 430 440 450
RAGDFNARSE ALQSIQEALG LADAPLRIEC VDISHVQGTD VVASLVVFED
460 470 480 490 500
GLPRKSDYRH YAIREAAGDG RSDDVASIAE VTRRRFLRHT SDSQPDPSAE
510 520 530 540 550
QRPRRFAYPP NLFVVDGGAP QVNAAAAVLE DLGVDDVAVI GLAKRLEEVW
560 570 580 590 600
VPSEPDPVIL PRNSEGLYLL QRVRDEAHRF AISYHRSKRS KRMTASALDS
610 620 630 640 650
VRGLGEHRRK ALVAHFGSVA RLKEATVDEI TAVPGIGVAT ARAVQEALGV
660 670 680 690 700
APQNGTAPDP APGTGDPQTP ADPHSAATAA DIEDDRHATG ATGPQMNGSE

QQVDRV
Length:706
Mass (Da):77,443
Last modified:January 9, 2007 - v1
Checksum:i576F941C487F429E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74829.1.
CP001663 Genomic DNA. Translation: AFP39464.1.
RefSeqiWP_011728800.1. NZ_CP009494.1.
YP_887394.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74829; ABK74829; MSMEG_3078.
AFP39464; AFP39464; MSMEI_3000.
GeneIDi4537665.
KEGGimsb:LJ00_15315.
msg:MSMEI_3000.
msm:MSMEG_3078.
PATRICi18078582. VBIMycSme59918_3039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74829.1.
CP001663 Genomic DNA. Translation: AFP39464.1.
RefSeqiWP_011728800.1. NZ_CP009494.1.
YP_887394.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QWV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_3078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74829; ABK74829; MSMEG_3078.
AFP39464; AFP39464; MSMEI_3000.
GeneIDi4537665.
KEGGimsb:LJ00_15315.
msg:MSMEI_3000.
msm:MSMEG_3078.
PATRICi18078582. VBIMycSme59918_3039.

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRC_MYCS2
AccessioniPrimary (citable) accession number: A0QWV6
Secondary accession number(s): I7GAF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.