Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:MSMEG_3064, MSMEI_2988
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201011 – 312Methionyl-tRNA formyltransferaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_3064

Structurei

3D structure databases

ProteinModelPortaliA0QWU2
SMRiA0QWU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

A0QWU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVFAGTPE PALPSLRRLI ESPRHDVVAV LTRPDAAAGR RGKPRPSPVA
60 70 80 90 100
QLALEHGIPL LRPDRPNSDE FVAELTELAP DCCAVVAYGA LLSQRLLAVP
110 120 130 140 150
RHGWINLHFS LLPAWRGAAP VQAAIAAGDT VTGATTFQIE PALDSGPVYG
160 170 180 190 200
VVTETVRDTD TAGDLLERLS DSGAELLERT IDGIADGSLT AVPQPSEGIT
210 220 230 240 250
VAPKITVESA RVRWDLPAHV VDRRIRAVTP NPGAWTMIGE LRVKVGPVTV
260 270 280 290 300
DQAAEADGPL APGEIRVGRN SVHVGTGSHP VRLGQIQPPG KKLMNAADWA
310
RGARLEEPVS AS
Length:312
Mass (Da):33,008
Last modified:January 9, 2007 - v1
Checksum:iF179910503BA9F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK70808.1
CP001663 Genomic DNA Translation: AFP39452.1
RefSeqiWP_011728792.1, NZ_CP009494.1
YP_887380.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK70808; ABK70808; MSMEG_3064
AFP39452; AFP39452; MSMEI_2988
GeneIDi4535023
KEGGimsb:LJ00_15245
msg:MSMEI_2988
msm:MSMEG_3064
PATRICifig|246196.19.peg.3025

Similar proteinsi

Entry informationi

Entry nameiFMT_MYCS2
AccessioniPrimary (citable) accession number: A0QWU2
Secondary accession number(s): I7G177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health