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A0QWQ9 (AROC_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:MSMEG_3030
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Chorismate synthase HAMAP MF_00300
PRO_0000322410

Sequences

Sequence LengthMass (Da)Tools
A0QWQ9 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 824E9AC671C6FF3A

FASTA39941,944
        10         20         30         40         50         60 
MLRWTTAGES HGRALVAMLE GMVAGVPITS EEIGAQLKRR RLGYGRGARM KFEQDQVTML 

        70         80         90        100        110        120 
AGVRHGLTLG GPIAIEIGNT EWPKWESVMS PDPVDPADLD VARNAPLTRP RPGHADYAGM 

       130        140        150        160        170        180 
LKYGFDDARP VLERASARET AARVAAGTVA RAFLREALGV EVLSHVISIG ASKPYDGPAP 

       190        200        210        220        230        240 
QFSDLSAIDD SPVRAFDKAS EELMIAEIEA AKRDGDTLGG VVEVVADGLP VGLGSFTSGE 

       250        260        270        280        290        300 
NRLDSQLAAA VMGIQAIKGV EIGDGFETAR RRGSVAHDEM YPGPDGVVRS TNRAGGLEGG 

       310        320        330        340        350        360 
MTNGQPLRVR AAMKPISTVP RALATVDMTS GEEAVAIHQR SDVCAVPAAG VVVETMVALV 

       370        380        390 
LARAALEKFG GDSLAETRAN IDSYLRAVAE REPAAQASS

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK72490.1.
RefSeqYP_887347.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0QWQ9.
SMRA0QWQ9. Positions 1-391.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QWQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000044813; EBMYCP00000043150; EBMYCG00000044808.
GeneID4533365.
GenomeReviewsGene locus MSMEG_3030 in contig CP000480_GR.
KEGGmsm:MSMEG_3030.
NMPDRfig|246196.1.peg.3044.
PATRIC18078488. VBIMycSme59918_2992.
TIGRMSMEG_3030.

Phylogenomic databases

eggNOGCOG0082.
GeneTreeEBGT00050000016560.
HOGENOMHBG292336.
OMAIQTITEN.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycMSME246196:MSMEG_3030-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_MYCS2
AccessionPrimary (citable) accession number: A0QWQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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