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Protein

Adenine phosphoribosyltransferase

Gene

apt

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (apt)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-2964-MONOMER.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.7UniRule annotation)
Short name:
APRTUniRule annotation
Gene namesi
Name:aptUniRule annotation
Ordered Locus Names:MSMEG_2964, MSMEI_2890
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Adenine phosphoribosyltransferasePRO_1000000311Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_2964.

Structurei

3D structure databases

ProteinModelPortaliA0QWJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4109003. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036776.
KOiK00759.
OMAiVHALCAF.
OrthoDBiPOG091H06AO.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr. 1 hit.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QWJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQHHDTAEV SRVIATLTRE VADFPEPGIQ FKDLTPLLAD ARGLRVVTDA
60 70 80 90 100
LADIASGADL VAGLDARGFL LGAAVATRLG TGVLAVRKGG KLPPPVHGAT
110 120 130 140 150
YQLEYGTATL EIPAEGIDIA GRNVVIIDDV LATGGTLAAA ARLLGDCGAN
160 170 180
VTGAGVVLEL EALRGREAVA PLGVRSLHII
Length:180
Mass (Da):18,385
Last modified:January 9, 2007 - v1
Checksum:i2344344598FB071D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71166.1.
CP001663 Genomic DNA. Translation: AFP39354.1.
RefSeqiWP_011728726.1. NZ_CP009494.1.
YP_887283.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK71166; ABK71166; MSMEG_2964.
AFP39354; AFP39354; MSMEI_2890.
GeneIDi4535093.
KEGGimsb:LJ00_14750.
msg:MSMEI_2890.
msm:MSMEG_2964.
PATRICi18078358. VBIMycSme59918_2927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71166.1.
CP001663 Genomic DNA. Translation: AFP39354.1.
RefSeqiWP_011728726.1. NZ_CP009494.1.
YP_887283.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QWJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_2964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK71166; ABK71166; MSMEG_2964.
AFP39354; AFP39354; MSMEI_2890.
GeneIDi4535093.
KEGGimsb:LJ00_14750.
msg:MSMEI_2890.
msm:MSMEG_2964.
PATRICi18078358. VBIMycSme59918_2927.

Phylogenomic databases

eggNOGiENOG4109003. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036776.
KOiK00759.
OMAiVHALCAF.
OrthoDBiPOG091H06AO.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00646.
BioCyciMSME246196:GJ4Y-2964-MONOMER.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr. 1 hit.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPT_MYCS2
AccessioniPrimary (citable) accession number: A0QWJ5
Secondary accession number(s): I7GA47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.