ID A0QWJ0_MYCS2 Unreviewed; 446 AA. AC A0QWJ0; DT 09-JAN-2007, integrated into UniProtKB/TrEMBL. DT 09-JAN-2007, sequence version 1. DT 27-MAR-2024, entry version 120. DE SubName: Full=4-aminobutyrate transaminase {ECO:0000313|EMBL:ABK73007.1}; DE EC=2.6.1.19 {ECO:0000313|EMBL:ABK73007.1}; GN Name=gabT {ECO:0000313|EMBL:ABK73007.1}; GN OrderedLocusNames=MSMEG_2959 {ECO:0000313|EMBL:ABK73007.1}; OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium OS smegmatis). OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; OC Mycolicibacterium. OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK73007.1, ECO:0000313|Proteomes:UP000000757}; RN [1] {ECO:0000313|EMBL:ABK73007.1, ECO:0000313|Proteomes:UP000000757} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757}; RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., RA Fraser C.M.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0007829|PDB:3OKS} RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-446. RX PubMed=25613812; DOI=10.1016/j.tube.2014.12.003; RA Baugh L., Phan I., Begley D.W., Clifton M.C., Armour B., Dranow D.M., RA Taylor B.M., Muruthi M.M., Abendroth J., Fairman J.W., Fox D., RA Dieterich S.H., Staker B.L., Gardberg A.S., Choi R., Hewitt S.N., RA Napuli A.J., Myers J., Barrett L.K., Zhang Y., Ferrell M., Mundt E., RA Thompkins K., Tran N., Lyons-Abbott S., Abramov A., Sekar A., RA Serbzhinskiy D., Lorimer D., Buchko G.W., Stacy R., Stewart L.J., RA Edwards T.E., Van Voorhis W.C., Myler P.J.; RT "Increasing the structural coverage of tuberculosis drug targets."; RL Tuberculosis 95:142-148(2015). CC -!- COFACTOR: CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; CC Evidence={ECO:0000256|ARBA:ARBA00001933}; CC -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent CC aminotransferase family. {ECO:0000256|ARBA:ARBA00008954, CC ECO:0000256|RuleBase:RU003560}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000480; ABK73007.1; -; Genomic_DNA. DR RefSeq; WP_011728721.1; NZ_SIJM01000002.1. DR RefSeq; YP_887278.1; NC_008596.1. DR PDB; 3OKS; X-ray; 1.80 A; A/B/C/D=2-446. DR PDBsum; 3OKS; -. DR AlphaFoldDB; A0QWJ0; -. DR SMR; A0QWJ0; -. DR STRING; 246196.MSMEG_2959; -. DR PaxDb; 246196-MSMEI_2885; -. DR GeneID; 66734367; -. DR KEGG; msm:MSMEG_2959; -. DR PATRIC; fig|246196.19.peg.2922; -. DR eggNOG; COG0160; Bacteria. DR OrthoDB; 9801052at2; -. DR EvolutionaryTrace; A0QWJ0; -. DR Proteomes; UP000000757; Chromosome. DR GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC. DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. DR GO; GO:0009448; P:gamma-aminobutyric acid metabolic process; IEA:InterPro. DR CDD; cd00610; OAT_like; 1. DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1. DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1. DR InterPro; IPR004632; 4NH2But_aminotransferase_bac. DR InterPro; IPR005814; Aminotrans_3. DR InterPro; IPR049704; Aminotrans_3_PPA_site. DR InterPro; IPR015424; PyrdxlP-dep_Trfase. DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major. DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small. DR NCBIfam; TIGR00700; GABAtrnsam; 1. DR PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1. DR Pfam; PF00202; Aminotran_3; 1. DR PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1. DR SUPFAM; SSF53383; PLP-dependent transferases; 1. DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:3OKS}; KW Aminotransferase {ECO:0000313|EMBL:ABK73007.1}; KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898, KW ECO:0000256|RuleBase:RU003560}; KW Reference proteome {ECO:0000313|Proteomes:UP000000757}; KW Transferase {ECO:0000313|EMBL:ABK73007.1}. SQ SEQUENCE 446 AA; 46926 MW; 5B94FA8EBC07306A CRC64; MSHPEQSRHL ATAIPGPRSQ ALIDRKGTAV ARGVGTTMPV YAVRAGGGIV EDVDGNRLID LGSGIAVTTV GNSAPKVVEA VRSQVGDFTH TCFMVTPYEG YVAVCEQLNR LTPVRGDKRS ALFNSGSEAV ENAVKIARSH THKPAVVAFD HAYHGRTNLT MALTAKVMPY KDGFGPFAPE IYRAPLSYPF RDAEFGKELA TDGELAAKRA ITVIDKQIGA DNLAAVVIEP IQGEGGFIVP ADGFLPTLLD WCRKNDVVFI ADEVQTGFAR TGAMFACEHE GIDPDLIVTA KGIAGGLPLS AVTGRAEIMD SPHVSGLGGT YGGNPIACAA ALATIETIES EGLVARAQQI EKIMKDRLGR LQAEDDRIGD VRGRGAMIAM ELVKAGTTEP DADLTKALCA GAHAAGVIVL SCGTYGNVVR FLPPLSIGDD LLNEGLDVLE EVLRGA //