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A0QWJ0

- A0QWJ0_MYCS2

UniProt

A0QWJ0 - A0QWJ0_MYCS2

Protein
Submitted name:

4-aminobutyrate aminotransferase

Gene

gabT

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    AminotransferaseImported, Transferase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-2959-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    4-aminobutyrate aminotransferaseImported (EC:2.6.1.19Imported)
    Submitted name:
    4-aminobutyrate transaminaseImported (EC:2.6.1.19Imported)
    Gene namesi
    Name:gabTImported
    Ordered Locus Names:MSMEG_2959Imported, MSMEI_2885Imported
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_2959.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3OKSX-ray1.80A/B/C/D2-446[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA0QWJ0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0160.
    HOGENOMiHOG000020206.
    KOiK07250.
    OMAiVYVERAK.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004632. 4NH2But_aminotransferase_bac.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QWJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHPEQSRHL ATAIPGPRSQ ALIDRKGTAV ARGVGTTMPV YAVRAGGGIV    50
    EDVDGNRLID LGSGIAVTTV GNSAPKVVEA VRSQVGDFTH TCFMVTPYEG 100
    YVAVCEQLNR LTPVRGDKRS ALFNSGSEAV ENAVKIARSH THKPAVVAFD 150
    HAYHGRTNLT MALTAKVMPY KDGFGPFAPE IYRAPLSYPF RDAEFGKELA 200
    TDGELAAKRA ITVIDKQIGA DNLAAVVIEP IQGEGGFIVP ADGFLPTLLD 250
    WCRKNDVVFI ADEVQTGFAR TGAMFACEHE GIDPDLIVTA KGIAGGLPLS 300
    AVTGRAEIMD SPHVSGLGGT YGGNPIACAA ALATIETIES EGLVARAQQI 350
    EKIMKDRLGR LQAEDDRIGD VRGRGAMIAM ELVKAGTTEP DADLTKALCA 400
    GAHAAGVIVL SCGTYGNVVR FLPPLSIGDD LLNEGLDVLE EVLRGA 446
    Length:446
    Mass (Da):46,926
    Last modified:January 9, 2007 - v1
    Checksum:i5B94FA8EBC07306A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK73007.1.
    CP001663 Genomic DNA. Translation: AFP39349.1.
    RefSeqiWP_011728721.1. NC_018289.1.
    YP_006567644.1. NC_018289.1.
    YP_887278.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK73007; ABK73007; MSMEG_2959.
    AFP39349; AFP39349; MSMEI_2885.
    GeneIDi4532510.
    KEGGimsg:MSMEI_2885.
    msm:MSMEG_2959.
    PATRICi18078348. VBIMycSme59918_2922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK73007.1 .
    CP001663 Genomic DNA. Translation: AFP39349.1 .
    RefSeqi WP_011728721.1. NC_018289.1.
    YP_006567644.1. NC_018289.1.
    YP_887278.1. NC_008596.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3OKS X-ray 1.80 A/B/C/D 2-446 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_2959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK73007 ; ABK73007 ; MSMEG_2959 .
    AFP39349 ; AFP39349 ; MSMEI_2885 .
    GeneIDi 4532510.
    KEGGi msg:MSMEI_2885.
    msm:MSMEG_2959.
    PATRICi 18078348. VBIMycSme59918_2922.

    Phylogenomic databases

    eggNOGi COG0160.
    HOGENOMi HOG000020206.
    KOi K07250.
    OMAi VYVERAK.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-2959-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei A0QWJ0.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004632. 4NH2But_aminotransferase_bac.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00700. GABAtrnsam. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MC2 155Imported.
    2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
    3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
    4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155 and MC2 155.
    5. "Crystal structure of 4-aminobutyrate transaminase from mycobacterium smegmatis."
      Gardberg A., Sankaran B., Abendroth J., Staker B., SSGCID
      Submitted (AUG-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-446.

    Entry informationi

    Entry nameiA0QWJ0_MYCS2
    AccessioniPrimary (citable) accession number: A0QWJ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3