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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-2613-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:MSMEG_2613, MSMEI_2551
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 510509Probable malate:quinone oxidoreductasePRO_0000325501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_2613.

Structurei

3D structure databases

ProteinModelPortaliA0QVL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiPOG091H0B7C.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0QVL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEANAGTNA KTDVVLVGAG IMSATLGTLI KLLEPNWSIT MIERLDGAAA
60 70 80 90 100
ESSDPWNNAG TGHSALCELN YTPALPDGTI DISKAVNVNE QFQVSRQFWA
110 120 130 140 150
HAVENGVLPD VRSFLNPVPH VSFVYGADNV QYLKARYNAL VTNPLFASME
160 170 180 190 200
FIDDKDEFTR RLPLMAEKRD FSEPVALNWS QHGTDVDFGS LSRQLIGFAA
210 220 230 240 250
GNGMTTMFGH DVRDLSKNSD GSWTVKVRNR RTGNNFKINA KFVFVGAGGG
260 270 280 290 300
ALPLLQKSGI PEAKGFGGFP VGGAFLRTNK QHLTSRHNAK VYGLPPLGAP
310 320 330 340 350
PMSVPHLDTR VINGRQWLLF GPFAGWSPKF LKQGKVTDLP LSVKPNNLAS
360 370 380 390 400
MLGVGLTEVG LLKYLIGQLL LSEPARVETL REFAPSAVDS DWELDIAGQR
410 420 430 440 450
VQVIRRKGAG GVLEFGTTVL AAADGSIAGL LGASPGASTA VPAMLDVLQR
460 470 480 490 500
CFADRYQAWT PKLKEMVPSL GTKLSDEPKL FEEVWSWGTK VLKLDVQANT
510
AEAANAPATV
Length:510
Mass (Da):54,914
Last modified:January 9, 2007 - v1
Checksum:i5B7D1BA26DDFBAF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72231.1.
CP001663 Genomic DNA. Translation: AFP39019.1.
RefSeqiWP_011728472.1. NZ_CP009494.1.
YP_886950.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK72231; ABK72231; MSMEG_2613.
AFP39019; AFP39019; MSMEI_2551.
GeneIDi4534593.
KEGGimsb:LJ00_13005.
msg:MSMEI_2551.
msm:MSMEG_2613.
PATRICi18077654. VBIMycSme59918_2579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72231.1.
CP001663 Genomic DNA. Translation: AFP39019.1.
RefSeqiWP_011728472.1. NZ_CP009494.1.
YP_886950.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QVL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_2613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK72231; ABK72231; MSMEG_2613.
AFP39019; AFP39019; MSMEI_2551.
GeneIDi4534593.
KEGGimsb:LJ00_13005.
msg:MSMEI_2551.
msm:MSMEG_2613.
PATRICi18077654. VBIMycSme59918_2579.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiPOG091H0B7C.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciMSME246196:GJ4Y-2613-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMQO_MYCS2
AccessioniPrimary (citable) accession number: A0QVL2
Secondary accession number(s): I7G8X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.