A0QVL2 (MQO_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	MSMEG_2613

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 510	509	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_0000325501

Sequences

	Sequence		Length	Mass (Da)
	A0QVL2 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 5B7D1BA26DDFBAF3	FASTA	510	54,914
	10 20 30 40 50 60 MSEANAGTNA KTDVVLVGAG IMSATLGTLI KLLEPNWSIT MIERLDGAAA ESSDPWNNAG 70 80 90 100 110 120 TGHSALCELN YTPALPDGTI DISKAVNVNE QFQVSRQFWA HAVENGVLPD VRSFLNPVPH 130 140 150 160 170 180 VSFVYGADNV QYLKARYNAL VTNPLFASME FIDDKDEFTR RLPLMAEKRD FSEPVALNWS 190 200 210 220 230 240 QHGTDVDFGS LSRQLIGFAA GNGMTTMFGH DVRDLSKNSD GSWTVKVRNR RTGNNFKINA 250 260 270 280 290 300 KFVFVGAGGG ALPLLQKSGI PEAKGFGGFP VGGAFLRTNK QHLTSRHNAK VYGLPPLGAP 310 320 330 340 350 360 PMSVPHLDTR VINGRQWLLF GPFAGWSPKF LKQGKVTDLP LSVKPNNLAS MLGVGLTEVG 370 380 390 400 410 420 LLKYLIGQLL LSEPARVETL REFAPSAVDS DWELDIAGQR VQVIRRKGAG GVLEFGTTVL 430 440 450 460 470 480 AAADGSIAGL LGASPGASTA VPAMLDVLQR CFADRYQAWT PKLKEMVPSL GTKLSDEPKL 490 500 510 FEEVWSWGTK VLKLDVQANT AEAANAPATV

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.
[2]	"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed: 18955433] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK72231.1.
RefSeq	YP_886950.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0QVL2.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QVL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000047018; EBMYCP00000045355; EBMYCG00000047013.
GeneID	4534593.
GenomeReviews	Gene locus MSMEG_2613 in contig CP000480_GR.
KEGG	msm:MSMEG_2613.
NMPDR	fig|246196.1.peg.2614.
PATRIC	18077654. VBIMycSme59918_2579.
TIGR	MSMEG_2613.
Phylogenomic databases
eggNOG	COG0579.
GeneTree	EBGT00050000015585.
HOGENOM	HBG289663.
OMA	KKWVPLM.
PhylomeDB	A0QVL2.
ProtClustDB	PRK05257.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_2613-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_MYCS2

Accession

Primary (citable) accession number: A0QVL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program