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Protein

Uridylate kinase

Gene

pyrH

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylation of UMP to UDP.UniRule annotation

Catalytic activityi

ATP + UMP = ADP + UDP.UniRule annotation

Enzyme regulationi

Inhibited by UTP.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UDP from UMP (UMPK route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridylate kinase (pyrH)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP from UMP (UMPK route), the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64UMP; via amide nitrogenUniRule annotation1
Binding sitei65ATP; via amide nitrogenUniRule annotation1
Binding sitei69ATPUniRule annotation1
Binding sitei84UMPUniRule annotation1
Binding sitei178ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei181ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 26ATPUniRule annotation4
Nucleotide bindingi145 – 152UMPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00275

Names & Taxonomyi

Protein namesi
Recommended name:
Uridylate kinaseUniRule annotation (EC:2.7.4.22UniRule annotation)
Short name:
UKUniRule annotation
Alternative name(s):
Uridine monophosphate kinaseUniRule annotation
Short name:
UMP kinaseUniRule annotation
Short name:
UMPKUniRule annotation
Gene namesi
Name:pyrHUniRule annotation
Ordered Locus Names:MSMEG_2540, MSMEI_2480
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003238872 – 248Uridylate kinaseAdd BLAST247

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_2540

Structurei

3D structure databases

ProteinModelPortaliA0QVD9
SMRiA0QVD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UMP kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C41 Bacteria
COG0528 LUCA
HOGENOMiHOG000047187
KOiK09903
OMAiPIIVFDM
OrthoDBiPOG091H02JZ

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01220_B PyrH_B, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR011817 Uridylate_kinase
IPR015963 Uridylate_kinase_bac
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF005650 Uridylate_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR02075 pyrH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0QVD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSNVAGRA APIRPLYTRV LLKLGGEMFG GGQVGLDPDV VAQVARQIAE
60 70 80 90 100
VVRSGAQVAV VIGGGNFFRG AQLQQRGMER TRSDYMGMLG TVMNSLALQD
110 120 130 140 150
FLQKEGIDTR VQTAITMGQV AEPYIPLRAV RHLEKGRVVI FGAGMGLPYF
160 170 180 190 200
STDTTAAQRA LEIGAEVVLM AKAVDGVFTD DPRTNPDAEL ITAISHREVI
210 220 230 240
DRGLKVADAT AFSLCMDNGM PILVFNLLTS GNIARAVAGE KIGTLVTT
Length:248
Mass (Da):26,363
Last modified:January 9, 2007 - v1
Checksum:i883175F5E0DC2E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK70978.1
CP001663 Genomic DNA Translation: AFP38948.1
RefSeqiWP_003893896.1, NZ_CP009494.1
YP_886877.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK70978; ABK70978; MSMEG_2540
AFP38948; AFP38948; MSMEI_2480
GeneIDi4535313
KEGGimsb:LJ00_12645
msg:MSMEI_2480
msm:MSMEG_2540
PATRICifig|246196.19.peg.2506

Similar proteinsi

Entry informationi

Entry nameiPYRH_MYCS2
AccessioniPrimary (citable) accession number: A0QVD9
Secondary accession number(s): I7FJN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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