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Protein

Ribonuclease HII

Gene

rnhB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Divalent metal cationUniRule annotation1
Metal bindingi37Divalent metal cationUniRule annotation1
Metal bindingi130Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-2442-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:MSMEG_2442, MSMEI_2381
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000311641 – 272Ribonuclease HIIAdd BLAST272

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_2442

Structurei

3D structure databases

ProteinModelPortaliA0QV44
SMRiA0QV44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UH2 Bacteria
COG0164 LUCA
HOGENOMiHOG000100288
KOiK03470
OMAiNILHASM
OrthoDBiPOG091H011N

Family and domain databases

CDDicd07182 RNase_HII_bacteria_HII_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00052_B RNase_HII_B, 1 hit
InterProiView protein in InterPro
IPR022898 RNase_HII
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PTHR10954:SF18 PTHR10954:SF18, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

A0QV44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSWPPRTV IRKSSGLRTL ESALYRNGLG PVAGVDEVGR GACAGPLVVA
60 70 80 90 100
ACVLGPNRLE SLAALDDSKK LGEKERERLF PLIRRYALAY HVVFIPSHEV
110 120 130 140 150
DRRGVHVANI EGMRRAVAGL SVRPGYVLSD GFRVPGLSVP SLPVIGGDAA
160 170 180 190 200
AACIAAASVL AKVSRDRLMV EMEEQHPGYG FAEHKGYITP AHTAALTRHG
210 220 230 240 250
PCVEHRYSYV NVRRAAEATG VRWASDRVGV RWSTESAAET EEVRRALEAF
260 270
EVEWVTAPVE HEDAACAKMG SG
Length:272
Mass (Da):29,300
Last modified:January 9, 2007 - v1
Checksum:i5975EDBBBA392761
GO

Sequence cautioni

The sequence AFP38849 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73838.1
CP001663 Genomic DNA Translation: AFP38849.1 Different initiation.
RefSeqiWP_011728344.1, NZ_CP009494.1
YP_886782.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK73838; ABK73838; MSMEG_2442
AFP38849; AFP38849; MSMEI_2381
GeneIDi4536492
KEGGimsb:LJ00_12145
msg:MSMEI_2381
msm:MSMEG_2442
PATRICifig|246196.19.peg.2407

Similar proteinsi

Entry informationi

Entry nameiRNH2_MYCS2
AccessioniPrimary (citable) accession number: A0QV44
Secondary accession number(s): I7G8A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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