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Protein

Acylphosphatase

Gene

acyP

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei27 – 271PROSITE-ProRule annotation
Active sitei45 – 451PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-2422-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase (EC:3.6.1.7)
Alternative name(s):
Acylphosphate phosphohydrolase
Gene namesi
Name:acyP
Ordered Locus Names:MSMEG_2422, MSMEI_2361
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898AcylphosphatasePRO_0000326750Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_2422.

Structurei

3D structure databases

ProteinModelPortaliA0QV24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 9887Acylphosphatase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108375. Bacteria.
COG1254. LUCA.
HOGENOMiHOG000292686.
KOiK01512.
OMAiTAWVHGY.
OrthoDBiEOG6ND0QX.

Family and domain databases

InterProiIPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QV24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGPGPRRDE ARLSAWVHGH VQGVGFRWWT RARALELGLT GFASNRPDGR
60 70 80 90
VHVVAQGSRE ACEKLLELLR SGETPGSVDK VIADWAEPDA TMTGFSER
Length:98
Mass (Da):10,756
Last modified:January 9, 2007 - v1
Checksum:i246B954B8B39D035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73038.1.
CP001663 Genomic DNA. Translation: AFP38829.1.
RefSeqiWP_011728332.1. NZ_CP009494.1.
YP_886762.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK73038; ABK73038; MSMEG_2422.
AFP38829; AFP38829; MSMEI_2361.
GeneIDi4534310.
KEGGimsb:LJ00_12045.
msg:MSMEI_2361.
msm:MSMEG_2422.
PATRICi18077270. VBIMycSme59918_2387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73038.1.
CP001663 Genomic DNA. Translation: AFP38829.1.
RefSeqiWP_011728332.1. NZ_CP009494.1.
YP_886762.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QV24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_2422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK73038; ABK73038; MSMEG_2422.
AFP38829; AFP38829; MSMEI_2361.
GeneIDi4534310.
KEGGimsb:LJ00_12045.
msg:MSMEI_2361.
msm:MSMEG_2422.
PATRICi18077270. VBIMycSme59918_2387.

Phylogenomic databases

eggNOGiENOG4108375. Bacteria.
COG1254. LUCA.
HOGENOMiHOG000292686.
KOiK01512.
OMAiTAWVHGY.
OrthoDBiEOG6ND0QX.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-2422-MONOMER.

Family and domain databases

InterProiIPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.

Entry informationi

Entry nameiACYP_MYCS2
AccessioniPrimary (citable) accession number: A0QV24
Secondary accession number(s): I7G869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 9, 2007
Last modified: November 11, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.