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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.27 3512

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:MSMEG_2399, MSMEI_2339
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000099131 – 227Uracil-DNA glycosylaseAdd BLAST227

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_2399

Structurei

3D structure databases

ProteinModelPortaliA0QV01
SMRiA0QV01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0QV01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARPLNELV EEGWARALEP VADQVAQMGE FLRTELAEGR QYLPAGQNVL
60 70 80 90 100
RAFTFPFDQV RVLIVGQDPY PTPGHAVGLS FSVAPDVRPL PRSLSNIFTE
110 120 130 140 150
YTEDLGHPQP SSGDLTPWAE RGVMLLNRVL TVRPGTPASH RGKGWEAVTE
160 170 180 190 200
CAIRALVARE QPLVAVLWGR DAATLKPMLA EGDCATIESP HPSPLSASRG
210 220
FFGSRPFSRV NELLQRRGIE PIDWKLP
Length:227
Mass (Da):24,967
Last modified:January 9, 2007 - v1
Checksum:i23EA3633604B3CFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71961.1
CP001663 Genomic DNA Translation: AFP38807.1
RefSeqiWP_003893765.1, NZ_CP009494.1
YP_886739.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK71961; ABK71961; MSMEG_2399
AFP38807; AFP38807; MSMEI_2339
GeneIDi4535802
KEGGimsb:LJ00_11930
msg:MSMEI_2339
msm:MSMEG_2399
PATRICifig|246196.19.peg.2363

Similar proteinsi

Entry informationi

Entry nameiUNG_MYCS2
AccessioniPrimary (citable) accession number: A0QV01
Secondary accession number(s): I7FZX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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