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A0QUX7

- ILVH_MYCS2

UniProt

A0QUX7 - ILVH_MYCS2

Protein

Acetolactate synthase small subunit

Gene

ilvH

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 pyruvate = 2-acetolactate + CO2.

    Pathwayi

    GO - Molecular functioni

    1. acetolactate synthase activity Source: UniProtKB-EC
    2. amino acid binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
    2. valine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-2373-MONOMER.
    UniPathwayiUPA00047; UER00055.
    UPA00049; UER00059.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetolactate synthase small subunit (EC:2.2.1.6)
    Alternative name(s):
    Acetohydroxy-acid synthase small subunit
    Short name:
    AHAS
    Short name:
    ALS
    Gene namesi
    Name:ilvH
    Synonyms:ilvN
    Ordered Locus Names:MSMEG_2373, MSMEI_2313
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Acetolactate synthase small subunitPRO_0000396815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki46 – 46Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Interactioni

    Subunit structurei

    Dimer of large and small chains.By similarity

    Protein-protein interaction databases

    STRINGi246196.MSMEG_2373.

    Structurei

    3D structure databases

    ProteinModelPortaliA0QUX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 8375ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0440.
    HOGENOMiHOG000046747.
    KOiK01653.
    OMAiTEGPHIE.
    OrthoDBiEOG6X3W8W.

    Family and domain databases

    InterProiIPR004789. Acetalactate_synth_ssu.
    IPR019455. Acetolactate_synth_ssu_C.
    IPR002912. ACT_dom.
    [Graphical view]
    PfamiPF10369. ALS_ss_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00119. acolac_sm. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QUX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNGTPTHTL SVLVEDKPGV LARVSSLFSR RGFNIQSLAV GATEQKDMSR    50
    MTIVVSVEDS PLEQITKQLN KLINVIKIVE QEEDNSVSRE LALIKVRADA 100
    TTRGQIIEAV NLFRAKVVDV STESLTIEAT GTPEKLEALL RVLEPYGIRE 150
    IAQSGVVSVS RGPRGIGAAK 170
    Length:170
    Mass (Da):18,395
    Last modified:January 9, 2007 - v1
    Checksum:iDDA5829FE67BC49D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK72789.1.
    CP001663 Genomic DNA. Translation: AFP38783.1.
    RefSeqiYP_006567078.1. NC_018289.1.
    YP_886715.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK72789; ABK72789; MSMEG_2373.
    AFP38783; AFP38783; MSMEI_2313.
    GeneIDi4532109.
    KEGGimsg:MSMEI_2313.
    msm:MSMEG_2373.
    PATRICi18077170. VBIMycSme59918_2339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK72789.1 .
    CP001663 Genomic DNA. Translation: AFP38783.1 .
    RefSeqi YP_006567078.1. NC_018289.1.
    YP_886715.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0QUX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_2373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK72789 ; ABK72789 ; MSMEG_2373 .
    AFP38783 ; AFP38783 ; MSMEI_2313 .
    GeneIDi 4532109.
    KEGGi msg:MSMEI_2313.
    msm:MSMEG_2373.
    PATRICi 18077170. VBIMycSme59918_2339.

    Phylogenomic databases

    eggNOGi COG0440.
    HOGENOMi HOG000046747.
    KOi K01653.
    OMAi TEGPHIE.
    OrthoDBi EOG6X3W8W.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00055 .
    UPA00049 ; UER00059 .
    BioCyci MSME246196:GJ4Y-2373-MONOMER.

    Family and domain databases

    InterProi IPR004789. Acetalactate_synth_ssu.
    IPR019455. Acetolactate_synth_ssu_C.
    IPR002912. ACT_dom.
    [Graphical view ]
    Pfami PF10369. ALS_ss_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00119. acolac_sm. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    4. Cited for: PUPYLATION AT LYS-46, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiILVH_MYCS2
    AccessioniPrimary (citable) accession number: A0QUX7
    Secondary accession number(s): I7FJ23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3