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A0QUX7 (ILVH_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetolactate synthase small subunit

EC=2.2.1.6
Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name=AHAS
Short name=ALS
Gene names
Name:ilvH
Synonyms:ilvN
Ordered Locus Names:MSMEG_2373, MSMEI_2313
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP]
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Subunit structure

Dimer of large and small chains By similarity.

Sequence similarities

Belongs to the acetolactate synthase small subunit family.

Contains 1 ACT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Acetolactate synthase small subunit
PRO_0000396815

Regions

Domain9 – 8375ACT

Amino acid modifications

Cross-link46Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Sequences

Sequence LengthMass (Da)Tools
A0QUX7 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: DDA5829FE67BC49D

FASTA17018,395
        10         20         30         40         50         60 
MSNGTPTHTL SVLVEDKPGV LARVSSLFSR RGFNIQSLAV GATEQKDMSR MTIVVSVEDS 

        70         80         90        100        110        120 
PLEQITKQLN KLINVIKIVE QEEDNSVSRE LALIKVRADA TTRGQIIEAV NLFRAKVVDV 

       130        140        150        160        170 
STESLTIEAT GTPEKLEALL RVLEPYGIRE IAQSGVVSVS RGPRGIGAAK 

« Hide

References

« Hide 'large scale' references
[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[2]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[3]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[4]"Expansion of the mycobacterial 'PUPylome'."
Watrous J., Burns K., Liu W.T., Patel A., Hook V., Bafna V., Barry C.E. III, Bark S., Dorrestein P.C.
Mol. Biosyst. 6:376-385(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PUPYLATION AT LYS-46, IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK72789.1.
CP001663 Genomic DNA. Translation: AFP38783.1.
RefSeqYP_006567078.1. NC_018289.1.
YP_886715.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0QUX7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_2373.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK72789; ABK72789; MSMEG_2373.
AFP38783; AFP38783; MSMEI_2313.
GeneID13428830.
4532109.
KEGGmsg:MSMEI_2313.
msm:MSMEG_2373.
PATRIC18077170. VBIMycSme59918_2339.

Phylogenomic databases

eggNOGCOG0440.
HOGENOMHOG000046747.
KOK01653.
OMARMTIVVN.
OrthoDBEOG6X3W8W.
ProtClustDBPRK11895.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-2373-MONOMER.
UniPathwayUPA00047; UER00055.
UPA00049; UER00059.

Family and domain databases

InterProIPR004789. Acetalactate_synth_ssu.
IPR019455. Acetolactate_synth_ssu_C.
IPR002912. ACT_dom.
[Graphical view]
PfamPF10369. ALS_ss_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00119. acolac_sm. 1 hit.
PROSITEPS51671. ACT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVH_MYCS2
AccessionPrimary (citable) accession number: A0QUX7
Secondary accession number(s): I7FJ23
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways