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A0QTQ6

- A0QTQ6_MYCS2

UniProt

A0QTQ6 - A0QTQ6_MYCS2

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Protein
Submitted name:

Protein serine/threonine phosphatase

Gene

MSMEG_1928

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi35 – 351MagnesiumCombined sources
Metal bindingi35 – 351ManganeseCombined sources
Metal bindingi185 – 1851MagnesiumCombined sources
Metal bindingi185 – 1851ManganeseCombined sources
Metal bindingi223 – 2231MagnesiumCombined sources
Metal bindingi223 – 2231ManganeseCombined sources

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

MagnesiumCombined sources, ManganeseCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1928-MONOMER.

Protein family/group databases

PptaseDBiP3D1109196.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein serine/threonine phosphataseImported (EC:3.1.3.16Imported)
Submitted name:
Regulatory proteinImported
Gene namesi
Ordered Locus Names:MSMEG_1928Imported, MSMEI_1887Imported
ORF Names:LJ00_09625Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1928.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JFRX-ray0.83A1-233[»]
2JFSX-ray1.45A1-233[»]
2JFTX-ray1.08A1-233[»]
2V06X-ray1.05A1-233[»]
SMRiA0QTQ6. Positions 1-233.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0QTQ6.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000235782.
KOiK01090.
OMAiVEANINY.
OrthoDBiEOG65N17S.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QTQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASVLSAATA TDQGPVRENN QDACLADGIL YAVADGFGAR GHHASATALK
60 70 80 90 100
TLSAGFAAAP DRDGLLEAVQ QANLRVFELL GDEPTVSGTT LTAVAVFEPG
110 120 130 140 150
QGGPLVVNIG DSPLYRIRDG HMEQLTDDHS VAGELVRMGE ITRHEARWHP
160 170 180 190 200
QRHLLTRALG IGPHIGPDVF GIDCGPGDRL LISSDGLFAA ADEALIVDAA
210 220 230
TSPDPQVAVR RLVEVANDAG GSDNTTVVVI DLG
Length:233
Mass (Da):24,198
Last modified:January 9, 2007 - v1
Checksum:i5BC95EDB6EC9C6C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75945.1.
CP001663 Genomic DNA. Translation: AFP38359.1.
CP009494 Genomic DNA. Translation: AIU07149.1.
RefSeqiYP_006566654.1. NC_018289.1.
YP_886294.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75945; ABK75945; MSMEG_1928.
AFP38359; AFP38359; MSMEI_1887.
GeneIDi4537738.
KEGGimsm:MSMEG_1928.
PATRICi18076305. VBIMycSme59918_1909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75945.1 .
CP001663 Genomic DNA. Translation: AFP38359.1 .
CP009494 Genomic DNA. Translation: AIU07149.1 .
RefSeqi YP_006566654.1. NC_018289.1.
YP_886294.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JFR X-ray 0.83 A 1-233 [» ]
2JFS X-ray 1.45 A 1-233 [» ]
2JFT X-ray 1.08 A 1-233 [» ]
2V06 X-ray 1.05 A 1-233 [» ]
SMRi A0QTQ6. Positions 1-233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_1928.

Protein family/group databases

PptaseDBi P3D1109196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK75945 ; ABK75945 ; MSMEG_1928 .
AFP38359 ; AFP38359 ; MSMEI_1887 .
GeneIDi 4537738.
KEGGi msm:MSMEG_1928.
PATRICi 18076305. VBIMycSme59918_1909.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000235782.
KOi K01090.
OMAi VEANINY.
OrthoDBi EOG65N17S.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-1928-MONOMER.

Miscellaneous databases

EvolutionaryTracei A0QTQ6.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  4. "Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases."
    Wehenkel A., Bellinzoni M., Schaeffer F., Villarino A., Alzari P.M.
    J. Mol. Biol. 374:890-898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  5. "Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme."
    Bellinzoni M., Wehenkel A., Shepard W., Alzari P.M.
    Structure 15:863-872(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (0.83 ANGSTROMS) IN COMPLEX WITH MANGANESE.
  6. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.
  7. "Complete Genome Sequence of Mycobacterium smegmatis Laboratory Strains (INHwt) and Isoniazid Resistant (INHR1/R2) Mutant Strains."
    Mohan A., Padiadpu J., Baloni P., Chandra N.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.

Entry informationi

Entry nameiA0QTQ6_MYCS2
AccessioniPrimary (citable) accession number: A0QTQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.