A0QTQ6 (A0QTQ6_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein serine/threonine phosphatase EMBL AFP38359.1
EC=3.1.3.16 EMBL AFP38359.1

Submitted name:
Regulatory protein EMBL ABK75945.1

Gene names

Ordered Locus Names:

MSMEG_1928 EMBL ABK75945.1, MSMEI_1887 EMBL AFP38359.1

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP] EMBL ABK75945.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium smegmatis

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium PDB 2JFR PDB 2JFT PDB 2V06 Manganese PDB 2JFR PDB 2JFT PDB 2JFS Metal-binding PDB 2JFR PDB 2JFT PDB 2V06 PDB 2JFS
Molecular function	Hydrolase EMBL AFP38359.1
Technical term	3D-structure PDB 2JFR PDB 2JFT PDB 2V06 PDB 2JFS Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	35	1	Magnesium PDB 2V06
	Metal binding	35	1	Manganese
	Metal binding	185	1	Magnesium PDB 2V06
	Metal binding	185	1	Manganese
	Metal binding	223	1	Magnesium PDB 2V06
	Metal binding	223	1	Manganese

Sequences

	Sequence		Length	Mass (Da)
	A0QTQ6 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 5BC95EDB6EC9C6C1	FASTA	233	24,198
	10 20 30 40 50 60 MASVLSAATA TDQGPVRENN QDACLADGIL YAVADGFGAR GHHASATALK TLSAGFAAAP 70 80 90 100 110 120 DRDGLLEAVQ QANLRVFELL GDEPTVSGTT LTAVAVFEPG QGGPLVVNIG DSPLYRIRDG 130 140 150 160 170 180 HMEQLTDDHS VAGELVRMGE ITRHEARWHP QRHLLTRALG IGPHIGPDVF GIDCGPGDRL 190 200 210 220 230 LISSDGLFAA ADEALIVDAA TSPDPQVAVR RLVEVANDAG GSDNTTVVVI DLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ICDS database: interrupted CoDing sequences in prokaryotic genomes." Perrodou E., Deshayes C., Muller J., Schaeffer C., Van Dorsselaer A., Ripp R., Poch O., Reyrat J.M., Lecompte O. Nucleic Acids Res. 34:D338-D343(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MC2 155 EMBL AFP38359.1.
[2]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL ABK75945.1.
[3]	"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?" Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M. Genome Biol. 8:R20-R20(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP38359.1.
[4]	"Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases." Wehenkel A., Bellinzoni M., Schaeffer F., Villarino A., Alzari P.M. J. Mol. Biol. 374:890-898(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
[5]	"Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme." Bellinzoni M., Wehenkel A., Shepard W., Alzari P.M. Structure 15:863-872(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (0.83 ANGSTROMS) IN COMPLEX WITH MANGANESE.
[6]	"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP38359.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000480 Genomic DNA. Translation: ABK75945.1.
CP001663 Genomic DNA. Translation: AFP38359.1.

RefSeq

YP_006566654.1. NC_018289.1.
YP_886294.1. NC_008596.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2JFR	X-ray	0.83	A	1-233	[»]
2JFS	X-ray	1.45	A	1-233	[»]
2JFT	X-ray	1.08	A	1-233	[»]
2V06	X-ray	1.05	A	1-233	[»]

SMR

A0QTQ6. Positions 1-233.

ModBase

Search...

Protein-protein interaction databases

STRING

246196.MSMEG_1928.

Protein family/group databases

PptaseDB

P3D1109196.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

ABK75945; ABK75945; MSMEG_1928.
AFP38359; AFP38359; MSMEI_1887.

GeneID

13428404.
4537738.

KEGG

msg:MSMEI_1887.
msm:MSMEG_1928.

PATRIC

18076305. VBIMycSme59918_1909.

Phylogenomic databases

eggNOG

COG0631.

HOGENOM

HOG000235782.

OMA

ARETRTH.

Enzyme and pathway databases

BioCyc

MSME246196:GJ4Y-1928-MONOMER.

Family and domain databases

Gene3D

3.60.40.10. 1 hit.

InterPro

IPR001932. PP2C-like.
IPR015655. Protein_Pase_2C.
[Graphical view]

PANTHER

PTHR13832. PTHR13832. 1 hit.

SMART

SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]

SUPFAM

SSF81606. PP2C-related. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

A0QTQ6.

Entry information

Entry name

A0QTQ6_MYCS2

Accession

Primary (citable) accession number: A0QTQ6

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)