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A0QTQ6

- A0QTQ6_MYCS2

UniProt

A0QTQ6 - A0QTQ6_MYCS2

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Protein
Submitted name: Protein serine/threonine phosphatase
Gene
MSMEG_1928, MSMEI_1887
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Chloride
Binding sitei17 – 171PhosphateImported
Metal bindingi35 – 351MagnesiumImported
Metal bindingi35 – 351ManganeseImported
Metal bindingi185 – 1851MagnesiumImported
Metal bindingi185 – 1851ManganeseImported
Binding sitei185 – 1851Cacodylate
Binding sitei185 – 1851PhosphateImported
Metal bindingi223 – 2231MagnesiumImported
Metal bindingi223 – 2231ManganeseImported
Binding sitei223 – 2231PhosphateImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

MagnesiumImported, ManganeseImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1928-MONOMER.

Protein family/group databases

PptaseDBiP3D1109196.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein serine/threonine phosphataseImported (EC:3.1.3.16Imported)
Submitted name:
Regulatory proteinImported
Gene namesi
Ordered Locus Names:MSMEG_1928Imported, MSMEI_1887Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1928.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JFRX-ray0.83A1-233[»]
2JFSX-ray1.45A1-233[»]
2JFTX-ray1.08A1-233[»]
2V06X-ray1.05A1-233[»]

Miscellaneous databases

EvolutionaryTraceiA0QTQ6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 362Cacodylate binding
Regioni35 – 362Phosphate bindingImported

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000235782.
KOiK01090.
OMAiITRHEAR.
OrthoDBiEOG65N17S.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QTQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MASVLSAATA TDQGPVRENN QDACLADGIL YAVADGFGAR GHHASATALK    50
TLSAGFAAAP DRDGLLEAVQ QANLRVFELL GDEPTVSGTT LTAVAVFEPG 100
QGGPLVVNIG DSPLYRIRDG HMEQLTDDHS VAGELVRMGE ITRHEARWHP 150
QRHLLTRALG IGPHIGPDVF GIDCGPGDRL LISSDGLFAA ADEALIVDAA 200
TSPDPQVAVR RLVEVANDAG GSDNTTVVVI DLG 233
Length:233
Mass (Da):24,198
Last modified:January 9, 2007 - v1
Checksum:i5BC95EDB6EC9C6C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK75945.1.
CP001663 Genomic DNA. Translation: AFP38359.1.
RefSeqiYP_006566654.1. NC_018289.1.
YP_886294.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75945; ABK75945; MSMEG_1928.
AFP38359; AFP38359; MSMEI_1887.
GeneIDi4537738.
KEGGimsg:MSMEI_1887.
msm:MSMEG_1928.
PATRICi18076305. VBIMycSme59918_1909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK75945.1 .
CP001663 Genomic DNA. Translation: AFP38359.1 .
RefSeqi YP_006566654.1. NC_018289.1.
YP_886294.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JFR X-ray 0.83 A 1-233 [» ]
2JFS X-ray 1.45 A 1-233 [» ]
2JFT X-ray 1.08 A 1-233 [» ]
2V06 X-ray 1.05 A 1-233 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_1928.

Protein family/group databases

PptaseDBi P3D1109196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK75945 ; ABK75945 ; MSMEG_1928 .
AFP38359 ; AFP38359 ; MSMEI_1887 .
GeneIDi 4537738.
KEGGi msg:MSMEI_1887.
msm:MSMEG_1928.
PATRICi 18076305. VBIMycSme59918_1909.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000235782.
KOi K01090.
OMAi ITRHEAR.
OrthoDBi EOG65N17S.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-1928-MONOMER.

Miscellaneous databases

EvolutionaryTracei A0QTQ6.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
  4. "Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases."
    Wehenkel A., Bellinzoni M., Schaeffer F., Villarino A., Alzari P.M.
    J. Mol. Biol. 374:890-898(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  5. "Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme."
    Bellinzoni M., Wehenkel A., Shepard W., Alzari P.M.
    Structure 15:863-872(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (0.83 ANGSTROMS) IN COMPLEX WITH CACODYLATE; MANGANESE AND PHOSPHATE.
  6. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.

Entry informationi

Entry nameiA0QTQ6_MYCS2
AccessioniPrimary (citable) accession number: A0QTQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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