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A0QTQ6

- A0QTQ6_MYCS2

UniProt

A0QTQ6 - A0QTQ6_MYCS2

Protein
Submitted name:

Protein serine/threonine phosphatase

Gene

MSMEG_1928

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151Chloride
    Metal bindingi35 – 351Magnesium
    Metal bindingi35 – 351ManganeseImported
    Metal bindingi185 – 1851Magnesium
    Metal bindingi185 – 1851ManganeseImported
    Binding sitei185 – 1851Cacodylate
    Metal bindingi223 – 2231Magnesium
    Metal bindingi223 – 2231ManganeseImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    HydrolaseImported

    Keywords - Ligandi

    MagnesiumImported, ManganeseImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-1928-MONOMER.

    Protein family/group databases

    PptaseDBiP3D1109196.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein serine/threonine phosphataseImported (EC:3.1.3.16Imported)
    Submitted name:
    Regulatory proteinImported
    Gene namesi
    Ordered Locus Names:MSMEG_1928Imported, MSMEI_1887Imported
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_1928.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JFRX-ray0.83A1-233[»]
    2JFSX-ray1.45A1-233[»]
    2JFTX-ray1.08A1-233[»]
    2V06X-ray1.05A1-233[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA0QTQ6.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 362Cacodylate binding

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000235782.
    KOiK01090.
    OMAiITRHEAR.
    OrthoDBiEOG65N17S.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0QTQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASVLSAATA TDQGPVRENN QDACLADGIL YAVADGFGAR GHHASATALK    50
    TLSAGFAAAP DRDGLLEAVQ QANLRVFELL GDEPTVSGTT LTAVAVFEPG 100
    QGGPLVVNIG DSPLYRIRDG HMEQLTDDHS VAGELVRMGE ITRHEARWHP 150
    QRHLLTRALG IGPHIGPDVF GIDCGPGDRL LISSDGLFAA ADEALIVDAA 200
    TSPDPQVAVR RLVEVANDAG GSDNTTVVVI DLG 233
    Length:233
    Mass (Da):24,198
    Last modified:January 9, 2007 - v1
    Checksum:i5BC95EDB6EC9C6C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75945.1.
    CP001663 Genomic DNA. Translation: AFP38359.1.
    RefSeqiYP_006566654.1. NC_018289.1.
    YP_886294.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK75945; ABK75945; MSMEG_1928.
    AFP38359; AFP38359; MSMEI_1887.
    GeneIDi4537738.
    KEGGimsg:MSMEI_1887.
    msm:MSMEG_1928.
    PATRICi18076305. VBIMycSme59918_1909.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75945.1 .
    CP001663 Genomic DNA. Translation: AFP38359.1 .
    RefSeqi YP_006566654.1. NC_018289.1.
    YP_886294.1. NC_008596.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JFR X-ray 0.83 A 1-233 [» ]
    2JFS X-ray 1.45 A 1-233 [» ]
    2JFT X-ray 1.08 A 1-233 [» ]
    2V06 X-ray 1.05 A 1-233 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_1928.

    Protein family/group databases

    PptaseDBi P3D1109196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK75945 ; ABK75945 ; MSMEG_1928 .
    AFP38359 ; AFP38359 ; MSMEI_1887 .
    GeneIDi 4537738.
    KEGGi msg:MSMEI_1887.
    msm:MSMEG_1928.
    PATRICi 18076305. VBIMycSme59918_1909.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000235782.
    KOi K01090.
    OMAi ITRHEAR.
    OrthoDBi EOG65N17S.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-1928-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei A0QTQ6.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MC2 155Imported.
    2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
    3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
    4. "Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases."
      Wehenkel A., Bellinzoni M., Schaeffer F., Villarino A., Alzari P.M.
      J. Mol. Biol. 374:890-898(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
    5. "Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme."
      Bellinzoni M., Wehenkel A., Shepard W., Alzari P.M.
      Structure 15:863-872(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (0.83 ANGSTROMS) IN COMPLEX WITH MANGANESE.
    6. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155 and MC2 155.

    Entry informationi

    Entry nameiA0QTQ6_MYCS2
    AccessioniPrimary (citable) accession number: A0QTQ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3