A0QT53 (ARAA_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	MSMEG_1715

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	L-arabinose isomerase HAMAP MF_00519		PRO_0000312613
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	333	1	Manganese By similarity
	Metal binding	350	1	Manganese By similarity
	Metal binding	449	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0QT53 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: FD2CFFE85A2ED960	FASTA	501	54,955
	10 20 30 40 50 60 MAEHFTDEEI WFVTGSQSLY GQEILDQVAE QSRALAERLD ASADLPVAVR WKPVVTTSEA 70 80 90 100 110 120 ILDVLRDASS SPQCVGVITW MHTFSPAKMW IRGLSALQKP MLHLHTQFGV EIPWDTIDMD 130 140 150 160 170 180 FMNLNQAAHG DREFGYIQTR LSVPRTTVAG HVGDPRTTAR IGSWMRAALG AAELRSLRIA 190 200 210 220 230 240 RFGDNMRDVA VTEGDKVEAE SHFGVSVNTY SVNDLAKAVY DVSDPEIDKL VQEYEDTYAV 250 260 270 280 290 300 AEELRRGGER HASLREGARI ELGLRHFLAD GFGAFTTNFE DLGDLRQLPG LAVQRLMADG 310 320 330 340 350 360 FGFGAEGDWK TSAMVRTVKT MGVGLPGGTS FMEDYTYDLT PGSERILGAH MLEVCPSIAG 370 380 390 400 410 420 QTPSLEVHPL GIGNREDPVR LRFTAAPGSG VVLGICDMGS RFRLVANHVT VVEPSAPLPN 430 440 450 460 470 480 LPVACAVWEP EPSWSTSTEA WLMAGGPHHT VLTTAVSPTT LDDFATITGT ELLQIDQHTT 490 500 PREFQREMRW NAVYHHIAAG L

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK71852.1.
RefSeq	YP_886091.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0QT53.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QT53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000043519; EBMYCP00000041856; EBMYCG00000043514.
GeneID	4535431.
GenomeReviews	Gene locus MSMEG_1715 in contig CP000480_GR.
KEGG	msm:MSMEG_1715.
NMPDR	fig|246196.1.peg.1711.
PATRIC	18075885. VBIMycSme59918_1699.
TIGR	MSMEG_1715.
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	A0QT53.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_1715-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_MYCS2

Accession

Primary (citable) accession number: A0QT53

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program