A0QT14 (A0QT14_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add HAMAP MF_00540
Ordered Locus Names:	MSMEG_1676

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK69908.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540
Ligand	Metal-binding HAMAP MF_00540 Zinc HAMAP MF_00540
Molecular function	Hydrolase HAMAP MF_00540 EMBL ABK69908.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	215	1	Proton donor By similarity HAMAP MF_00540
	Metal binding	23	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	25	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	212	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	304	1	Zinc; catalytic By similarity HAMAP MF_00540
	Binding site	25	1	Substrate By similarity HAMAP MF_00540
	Binding site	27	1	Substrate By similarity HAMAP MF_00540
	Binding site	185	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
	Site	236	1	Important for catalytic activity By similarity HAMAP MF_00540

Sequences

	Sequence		Length	Mass (Da)
	A0QT14 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: A8AD7A11DFF76769	FASTA	366	39,973
	10 20 30 40 50 60 MMEGMSTPLS LEKITNAPKA LLHDHLDGGL RPATVLDLAG QVGYDNLPAT DADELATFFR 70 80 90 100 110 120 TAAHSGSLVR YLEPFAHTVG VMQTPEALHR VAFECVEDLA ADNVVYAEVR FAPELHIDGG 130 140 150 160 170 180 LSLDDVVDAV LAGFADGEKA SAAAGRTIVV RCLVTAMRHA ARSREIAELA IRFRDKGVVG 190 200 210 220 230 240 FDIAGAEAGY PPSRHLDAFE YMRSNNARFT IHAGEAFGLP SIHEAIAFCG ADRLGHGVRI 250 260 270 280 290 300 VDDISETPDG TQQLGRLASL LRDKRIPLEM CPSSNVQTGA VKSIAEHPFD RLARLRFRVT 310 320 330 340 350 360 VNTDNRLMSD TTMSQEMHRL VEAFGYGWSD LERFTINAMK SAFIPFDQRL AIIDEVIKPR YAVLVG

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK69908.1.
RefSeq	YP_886052.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0QT14.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QT14.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000042554; EBMYCP00000040891; EBMYCG00000042549.
GeneID	4534008.
GenomeReviews	Gene locus MSMEG_1676 in contig CP000480_GR.
KEGG	msm:MSMEG_1676.
NMPDR	fig|246196.1.peg.1673.
PATRIC	18075807. VBIMycSme59918_1660.
TIGR	MSMEG_1676.
Phylogenomic databases
eggNOG	COG1816.
GeneTree	EBGT00050000016615.
HOGENOM	HBG630382.
OMA	PYYMAMN.
PhylomeDB	A0QT14.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0QT14_MYCS2

Accession

Primary (citable) accession number: A0QT14

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)