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A0QSZ3

- A0QSZ3_MYCS2

UniProt

A0QSZ3 - A0QSZ3_MYCS2

Protein
Submitted name:

Isocitrate dehydrogenase (NADP) Icd2

Gene

icd2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganese
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei550 – 5501SubstrateUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganese
    Metal bindingi555 – 5551Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-1654-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase (NADP) Icd2Imported (EC:1.1.1.42Imported)
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icd2Imported
    Ordered Locus Names:MSMEG_1654Imported, MSMEI_1615Imported
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006158: Chromosome, UP000000757: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_1654.

    Structurei

    3D structure databases

    SMRiA0QSZ3. Positions 6-740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiSIVKLMQ.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0QSZ3-1 [UniParc]FASTAAdd to Basket

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    MSAQQPTIIY TLTDEAPLLA TYAFLPVVRK FAEAAGIDVK TSDISVAARI    50
    LAEFGDHLTE EQRVPDNLGE LGALTQDPSA NIIKLPNISA SVPQLLAAIK 100
    ELQGKGYNVP DYPANPKTDD EKKIKDRYAK ILGSAVNPVL REGNSDRRAP 150
    KAVKEYARKH PHSMGEWSQA SRTHVATMKT GDFYHGEKSM TLDRDRRVKM 200
    VLKTKSGEEI VLKPEVKLDA GDIIDSMYMS KKALIAFYEE QIEDAYKTGV 250
    MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHEKLFDE LGVNVNNGLS 300
    DLYDKIEALP ASQREEIIED LHKCHEHRPE LAMVDSAKGI SNFHSPSDVI 350
    VDASMPAMIR LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINFCKTHGQ 400
    FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPEDGVADIV DIDTGEVLLT 450
    QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA RLSGMPVVFW LDTERPHEVE 500
    LRKKVKEYLK DHDTEGLKIQ IMPQVWAMRY TLERVVRGKD TIAATGNILR 550
    DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVHQLVEEN 600
    HLRWDSLGEF LALGASLEDM GNKTGNEKAK VLAKALDTAT GKLLEENKSP 650
    SRRTGELDNR GSQFYLSLFW AQALAEQTED AELAERFKPL AKALAEQEEA 700
    IVSELNSVQG KTVDIGGYYY PDPEKTSEVM RPSKTFNTTL ESV 743
    Length:743
    Mass (Da):82,604
    Last modified:January 9, 2007 - v1
    Checksum:iC30D68DBA13A1198
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK69615.1.
    CP001663 Genomic DNA. Translation: AFP38087.1.
    RefSeqiYP_006566382.1. NC_018289.1.
    YP_886031.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK69615; ABK69615; MSMEG_1654.
    AFP38087; AFP38087; MSMEI_1615.
    GeneIDi4535441.
    KEGGimsg:MSMEI_1615.
    msm:MSMEG_1654.
    PATRICi18075765. VBIMycSme59918_1639.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK69615.1 .
    CP001663 Genomic DNA. Translation: AFP38087.1 .
    RefSeqi YP_006566382.1. NC_018289.1.
    YP_886031.1. NC_008596.1.

    3D structure databases

    SMRi A0QSZ3. Positions 6-740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_1654.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK69615 ; ABK69615 ; MSMEG_1654 .
    AFP38087 ; AFP38087 ; MSMEI_1615 .
    GeneIDi 4535441.
    KEGGi msg:MSMEI_1615.
    msm:MSMEG_1654.
    PATRICi 18075765. VBIMycSme59918_1639.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi SIVKLMQ.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-1654-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MC2 155Imported.
    2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
    3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
    4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155 and MC2 155.

    Entry informationi

    Entry nameiA0QSZ3_MYCS2
    AccessioniPrimary (citable) accession number: A0QSZ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3