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A0QSZ3

- A0QSZ3_MYCS2

UniProt

A0QSZ3 - A0QSZ3_MYCS2

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Protein
Submitted name: Isocitrate dehydrogenase (NADP) Icd2
Gene
icd2, MSMEG_1654, MSMEI_1615
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei550 – 5501Substrate By similarityUniRule annotation
Metal bindingi551 – 5511Magnesium or manganese By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1654-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP) Icd2Imported (EC:1.1.1.42Imported)
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Name:icd2Imported
Ordered Locus Names:MSMEG_1654Imported, MSMEI_1615Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1654.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiSIVKLMQ.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QSZ3-1 [UniParc]FASTAAdd to Basket

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MSAQQPTIIY TLTDEAPLLA TYAFLPVVRK FAEAAGIDVK TSDISVAARI    50
LAEFGDHLTE EQRVPDNLGE LGALTQDPSA NIIKLPNISA SVPQLLAAIK 100
ELQGKGYNVP DYPANPKTDD EKKIKDRYAK ILGSAVNPVL REGNSDRRAP 150
KAVKEYARKH PHSMGEWSQA SRTHVATMKT GDFYHGEKSM TLDRDRRVKM 200
VLKTKSGEEI VLKPEVKLDA GDIIDSMYMS KKALIAFYEE QIEDAYKTGV 250
MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHEKLFDE LGVNVNNGLS 300
DLYDKIEALP ASQREEIIED LHKCHEHRPE LAMVDSAKGI SNFHSPSDVI 350
VDASMPAMIR LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINFCKTHGQ 400
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPEDGVADIV DIDTGEVLLT 450
QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA RLSGMPVVFW LDTERPHEVE 500
LRKKVKEYLK DHDTEGLKIQ IMPQVWAMRY TLERVVRGKD TIAATGNILR 550
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVHQLVEEN 600
HLRWDSLGEF LALGASLEDM GNKTGNEKAK VLAKALDTAT GKLLEENKSP 650
SRRTGELDNR GSQFYLSLFW AQALAEQTED AELAERFKPL AKALAEQEEA 700
IVSELNSVQG KTVDIGGYYY PDPEKTSEVM RPSKTFNTTL ESV 743
Length:743
Mass (Da):82,604
Last modified:January 9, 2007 - v1
Checksum:iC30D68DBA13A1198
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK69615.1.
CP001663 Genomic DNA. Translation: AFP38087.1.
RefSeqiYP_006566382.1. NC_018289.1.
YP_886031.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK69615; ABK69615; MSMEG_1654.
AFP38087; AFP38087; MSMEI_1615.
GeneIDi4535441.
KEGGimsg:MSMEI_1615.
msm:MSMEG_1654.
PATRICi18075765. VBIMycSme59918_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK69615.1 .
CP001663 Genomic DNA. Translation: AFP38087.1 .
RefSeqi YP_006566382.1. NC_018289.1.
YP_886031.1. NC_008596.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_1654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK69615 ; ABK69615 ; MSMEG_1654 .
AFP38087 ; AFP38087 ; MSMEI_1615 .
GeneIDi 4535441.
KEGGi msg:MSMEI_1615.
msm:MSMEG_1654.
PATRICi 18075765. VBIMycSme59918_1639.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi SIVKLMQ.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-1654-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
  4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.

Entry informationi

Entry nameiA0QSZ3_MYCS2
AccessioniPrimary (citable) accession number: A0QSZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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