Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0QSZ3

- A0QSZ3_MYCS2

UniProt

A0QSZ3 - A0QSZ3_MYCS2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Isocitrate dehydrogenase (NADP) Icd2

Gene

icd2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1654-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP) Icd2Imported (EC:1.1.1.42Imported)
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Name:icd2Imported
Ordered Locus Names:MSMEG_1654Imported, MSMEI_1615Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1654.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiSIVKLMQ.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QSZ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAQQPTIIY TLTDEAPLLA TYAFLPVVRK FAEAAGIDVK TSDISVAARI
60 70 80 90 100
LAEFGDHLTE EQRVPDNLGE LGALTQDPSA NIIKLPNISA SVPQLLAAIK
110 120 130 140 150
ELQGKGYNVP DYPANPKTDD EKKIKDRYAK ILGSAVNPVL REGNSDRRAP
160 170 180 190 200
KAVKEYARKH PHSMGEWSQA SRTHVATMKT GDFYHGEKSM TLDRDRRVKM
210 220 230 240 250
VLKTKSGEEI VLKPEVKLDA GDIIDSMYMS KKALIAFYEE QIEDAYKTGV
260 270 280 290 300
MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHEKLFDE LGVNVNNGLS
310 320 330 340 350
DLYDKIEALP ASQREEIIED LHKCHEHRPE LAMVDSAKGI SNFHSPSDVI
360 370 380 390 400
VDASMPAMIR LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINFCKTHGQ
410 420 430 440 450
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPEDGVADIV DIDTGEVLLT
460 470 480 490 500
QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA RLSGMPVVFW LDTERPHEVE
510 520 530 540 550
LRKKVKEYLK DHDTEGLKIQ IMPQVWAMRY TLERVVRGKD TIAATGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVHQLVEEN
610 620 630 640 650
HLRWDSLGEF LALGASLEDM GNKTGNEKAK VLAKALDTAT GKLLEENKSP
660 670 680 690 700
SRRTGELDNR GSQFYLSLFW AQALAEQTED AELAERFKPL AKALAEQEEA
710 720 730 740
IVSELNSVQG KTVDIGGYYY PDPEKTSEVM RPSKTFNTTL ESV
Length:743
Mass (Da):82,604
Last modified:January 9, 2007 - v1
Checksum:iC30D68DBA13A1198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69615.1.
CP001663 Genomic DNA. Translation: AFP38087.1.
RefSeqiYP_006566382.1. NC_018289.1.
YP_886031.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK69615; ABK69615; MSMEG_1654.
AFP38087; AFP38087; MSMEI_1615.
GeneIDi4535441.
KEGGimsm:MSMEG_1654.
PATRICi18075765. VBIMycSme59918_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69615.1 .
CP001663 Genomic DNA. Translation: AFP38087.1 .
RefSeqi YP_006566382.1. NC_018289.1.
YP_886031.1. NC_008596.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_1654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK69615 ; ABK69615 ; MSMEG_1654 .
AFP38087 ; AFP38087 ; MSMEI_1615 .
GeneIDi 4535441.
KEGGi msm:MSMEG_1654.
PATRICi 18075765. VBIMycSme59918_1639.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi SIVKLMQ.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-1654-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.

Entry informationi

Entry nameiA0QSZ3_MYCS2
AccessioniPrimary (citable) accession number: A0QSZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3