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A0QSZ3 (A0QSZ3_MYCS2) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=1.1.1.42 EMBL AFP38087.1

Isocitrate dehydrogenase, NADP-dependent EMBL ABK69615.1
EC=1.1.1.42 EMBL ABK69615.1
Gene names
Name:icd2 EMBL AFP38087.1
Ordered Locus Names:MSMEG_1654 EMBL ABK69615.1, MSMEI_1615 EMBL AFP38087.1
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP] EMBL ABK69615.1
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region134 – 1418Substrate binding By similarity PIRSR PIRSR009407-2

Sites

Metal binding3521Magnesium or manganese By similarity PIRSR PIRSR009407-3
Metal binding5511Magnesium or manganese By similarity PIRSR PIRSR009407-3
Metal binding5551Magnesium or manganese By similarity PIRSR PIRSR009407-3
Binding site1471Substrate By similarity PIRSR PIRSR009407-2
Binding site5501Substrate By similarity PIRSR PIRSR009407-2
Site2571Critical for catalysis By similarity PIRSR PIRSR009407-1
Site4221Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

Sequence LengthMass (Da)Tools
A0QSZ3 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: C30D68DBA13A1198

FASTA74382,604
        10         20         30         40         50         60 
MSAQQPTIIY TLTDEAPLLA TYAFLPVVRK FAEAAGIDVK TSDISVAARI LAEFGDHLTE 

        70         80         90        100        110        120 
EQRVPDNLGE LGALTQDPSA NIIKLPNISA SVPQLLAAIK ELQGKGYNVP DYPANPKTDD 

       130        140        150        160        170        180 
EKKIKDRYAK ILGSAVNPVL REGNSDRRAP KAVKEYARKH PHSMGEWSQA SRTHVATMKT 

       190        200        210        220        230        240 
GDFYHGEKSM TLDRDRRVKM VLKTKSGEEI VLKPEVKLDA GDIIDSMYMS KKALIAFYEE 

       250        260        270        280        290        300 
QIEDAYKTGV MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHEKLFDE LGVNVNNGLS 

       310        320        330        340        350        360 
DLYDKIEALP ASQREEIIED LHKCHEHRPE LAMVDSAKGI SNFHSPSDVI VDASMPAMIR 

       370        380        390        400        410        420 
LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINFCKTHGQ FDPTTMGTVP NVGLMAQKAE 

       430        440        450        460        470        480 
EYGSHDKTFE IPEDGVADIV DIDTGEVLLT QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA 

       490        500        510        520        530        540 
RLSGMPVVFW LDTERPHEVE LRKKVKEYLK DHDTEGLKIQ IMPQVWAMRY TLERVVRGKD 

       550        560        570        580        590        600 
TIAATGNILR DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVHQLVEEN 

       610        620        630        640        650        660 
HLRWDSLGEF LALGASLEDM GNKTGNEKAK VLAKALDTAT GKLLEENKSP SRRTGELDNR 

       670        680        690        700        710        720 
GSQFYLSLFW AQALAEQTED AELAERFKPL AKALAEQEEA IVSELNSVQG KTVDIGGYYY 

       730        740 
PDPEKTSEVM RPSKTFNTTL ESV 

« Hide

References

« Hide 'large scale' references
[1]"ICDS database: interrupted CoDing sequences in prokaryotic genomes."
Perrodou E., Deshayes C., Muller J., Schaeffer C., Van Dorsselaer A., Ripp R., Poch O., Reyrat J.M., Lecompte O.
Nucleic Acids Res. 34:D338-D343(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MC2 155 EMBL AFP38087.1.
[2]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL ABK69615.1.
[3]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP38087.1.
[4]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155 and MC2 155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK69615.1.
CP001663 Genomic DNA. Translation: AFP38087.1.
RefSeqYP_006566382.1. NC_018289.1.
YP_886031.1. NC_008596.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_1654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK69615; ABK69615; MSMEG_1654.
AFP38087; AFP38087; MSMEI_1615.
GeneID13429428.
4535441.
KEGGmsg:MSMEI_1615.
msm:MSMEG_1654.
PATRIC18075765. VBIMycSme59918_1639.

Phylogenomic databases

eggNOGCOG2838.
HOGENOMHOG000240860.
KOK00031.
OMAGYLRWDS.
OrthoDBEOG6DVJPP.
ProtClustDBCLSK867411.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-1654-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 3 hits.
InterProIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamPF03971. IDH. 1 hit.
[Graphical view]
PIRSFPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsTIGR00178. monomer_idh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0QSZ3_MYCS2
AccessionPrimary (citable) accession number: A0QSZ3
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)