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Protein
Submitted name:

Isocitrate dehydrogenase (NADP) Icd2

Gene

icd2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1654-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP) Icd2Imported (EC:1.1.1.42Imported)
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Submitted name:
Mycobacterium smegmatis str. MC2 155, complete genomeImported (EC:1.1.1.42Imported)
Gene namesi
Name:icd2Imported
Ordered Locus Names:MSMEG_1654Imported, MSMEI_1615Imported
ORF Names:LJ00_08265Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000006158 Componenti: Chromosome UP000029906 Componenti: Chromosome UP000000757 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1654.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QSZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQQPTIIY TLTDEAPLLA TYAFLPVVRK FAEAAGIDVK TSDISVAARI
60 70 80 90 100
LAEFGDHLTE EQRVPDNLGE LGALTQDPSA NIIKLPNISA SVPQLLAAIK
110 120 130 140 150
ELQGKGYNVP DYPANPKTDD EKKIKDRYAK ILGSAVNPVL REGNSDRRAP
160 170 180 190 200
KAVKEYARKH PHSMGEWSQA SRTHVATMKT GDFYHGEKSM TLDRDRRVKM
210 220 230 240 250
VLKTKSGEEI VLKPEVKLDA GDIIDSMYMS KKALIAFYEE QIEDAYKTGV
260 270 280 290 300
MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHEKLFDE LGVNVNNGLS
310 320 330 340 350
DLYDKIEALP ASQREEIIED LHKCHEHRPE LAMVDSAKGI SNFHSPSDVI
360 370 380 390 400
VDASMPAMIR LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINFCKTHGQ
410 420 430 440 450
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE IPEDGVADIV DIDTGEVLLT
460 470 480 490 500
QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA RLSGMPVVFW LDTERPHEVE
510 520 530 540 550
LRKKVKEYLK DHDTEGLKIQ IMPQVWAMRY TLERVVRGKD TIAATGNILR
560 570 580 590 600
DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVHQLVEEN
610 620 630 640 650
HLRWDSLGEF LALGASLEDM GNKTGNEKAK VLAKALDTAT GKLLEENKSP
660 670 680 690 700
SRRTGELDNR GSQFYLSLFW AQALAEQTED AELAERFKPL AKALAEQEEA
710 720 730 740
IVSELNSVQG KTVDIGGYYY PDPEKTSEVM RPSKTFNTTL ESV
Length:743
Mass (Da):82,604
Last modified:January 9, 2007 - v1
Checksum:iC30D68DBA13A1198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69615.1.
CP001663 Genomic DNA. Translation: AFP38087.1.
CP009494 Genomic DNA. Translation: AIU06885.1.
RefSeqiWP_011727802.1. NC_018289.1.
YP_006566382.1. NC_018289.1.
YP_886031.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK69615; ABK69615; MSMEG_1654.
AFP38087; AFP38087; MSMEI_1615.
AIU06885; AIU06885; LJ00_08265.
GeneIDi4535441.
KEGGimsm:MSMEG_1654.
PATRICi18075765. VBIMycSme59918_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69615.1.
CP001663 Genomic DNA. Translation: AFP38087.1.
CP009494 Genomic DNA. Translation: AIU06885.1.
RefSeqiWP_011727802.1. NC_018289.1.
YP_006566382.1. NC_018289.1.
YP_886031.1. NC_008596.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_1654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK69615; ABK69615; MSMEG_1654.
AFP38087; AFP38087; MSMEI_1615.
AIU06885; AIU06885; LJ00_08265.
GeneIDi4535441.
KEGGimsm:MSMEG_1654.
PATRICi18075765. VBIMycSme59918_1639.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1654-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.
  5. "Complete genome sequences of a Mycobacterium smegmatis laboratory strain (MC2 155) and isoniazid-resistant (4XR1/R2) mutant strains."
    Mohan A., Padiadpu J., Baloni P., Chandra N.
    Genome Announc. 3:E01520-E01520(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.

Entry informationi

Entry nameiA0QSZ3_MYCS2
AccessioniPrimary (citable) accession number: A0QSZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.