A0QSZ3 (A0QSZ3_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase (NADP) Icd2 EMBL AFP38087.1
EC=1.1.1.42 EMBL AFP38087.1

Submitted name:
Isocitrate dehydrogenase, NADP-dependent EMBL ABK69615.1
EC=1.1.1.42 EMBL ABK69615.1

Gene names

Name:	icd2 EMBL AFP38087.1
Ordered Locus Names:	MSMEG_1654 EMBL ABK69615.1, MSMEI_1615 EMBL AFP38087.1

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP] EMBL ABK69615.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium smegmatis

Protein attributes

Sequence length	743 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL ABK69615.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	134 – 141	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	352	1	Magnesium or manganese By similarity
	Metal binding	551	1	Magnesium or manganese By similarity
	Metal binding	555	1	Magnesium or manganese By similarity
	Binding site	147	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	550	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	257	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	422	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	A0QSZ3 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: C30D68DBA13A1198	FASTA	743	82,604
	10 20 30 40 50 60 MSAQQPTIIY TLTDEAPLLA TYAFLPVVRK FAEAAGIDVK TSDISVAARI LAEFGDHLTE 70 80 90 100 110 120 EQRVPDNLGE LGALTQDPSA NIIKLPNISA SVPQLLAAIK ELQGKGYNVP DYPANPKTDD 130 140 150 160 170 180 EKKIKDRYAK ILGSAVNPVL REGNSDRRAP KAVKEYARKH PHSMGEWSQA SRTHVATMKT 190 200 210 220 230 240 GDFYHGEKSM TLDRDRRVKM VLKTKSGEEI VLKPEVKLDA GDIIDSMYMS KKALIAFYEE 250 260 270 280 290 300 QIEDAYKTGV MFSLHVKATM MKVSHPIVFG HAVKVFYKDA FAKHEKLFDE LGVNVNNGLS 310 320 330 340 350 360 DLYDKIEALP ASQREEIIED LHKCHEHRPE LAMVDSAKGI SNFHSPSDVI VDASMPAMIR 370 380 390 400 410 420 LGGKMYGADG RTKDTKAVNP ESTFSRMYQE MINFCKTHGQ FDPTTMGTVP NVGLMAQKAE 430 440 450 460 470 480 EYGSHDKTFE IPEDGVADIV DIDTGEVLLT QNVEEGDIWR MPIVKDAPIR DWVKLAVTRA 490 500 510 520 530 540 RLSGMPVVFW LDTERPHEVE LRKKVKEYLK DHDTEGLKIQ IMPQVWAMRY TLERVVRGKD 550 560 570 580 590 600 TIAATGNILR DYLTDLFPIL ELGTSAKMLS IVPLMAGGGL YETGAGGSAP KHVHQLVEEN 610 620 630 640 650 660 HLRWDSLGEF LALGASLEDM GNKTGNEKAK VLAKALDTAT GKLLEENKSP SRRTGELDNR 670 680 690 700 710 720 GSQFYLSLFW AQALAEQTED AELAERFKPL AKALAEQEEA IVSELNSVQG KTVDIGGYYY 730 740 PDPEKTSEVM RPSKTFNTTL ESV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ICDS database: interrupted CoDing sequences in prokaryotic genomes." Perrodou E., Deshayes C., Muller J., Schaeffer C., Van Dorsselaer A., Ripp R., Poch O., Reyrat J.M., Lecompte O. Nucleic Acids Res. 34:D338-D343(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MC2 155 EMBL AFP38087.1.
[2]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL ABK69615.1.
[3]	"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?" Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M. Genome Biol. 8:R20-R20(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP38087.1.
[4]	"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP38087.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK69615.1. CP001663 Genomic DNA. Translation: AFP38087.1.
RefSeq	YP_006566382.1. NC_018289.1. YP_886031.1. NC_008596.1.
3D structure databases
SMR	A0QSZ3. Positions 6-740.
ModBase	Search...
Protein-protein interaction databases
STRING	246196.MSMEG_1654.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK69615; ABK69615; MSMEG_1654. AFP38087; AFP38087; MSMEI_1615.
GeneID	13429428. 4535441.
KEGG	msg:MSMEI_1615. msm:MSMEG_1654.
PATRIC	18075765. VBIMycSme59918_1639.
Phylogenomic databases
eggNOG	COG2838.
HOGENOM	HOG000240860.
KO	K00031.
OMA	PRTMGTV.
ProtClustDB	CLSK867411.
Enzyme and pathway databases
BioCyc	MSME246196:GJ4Y-1654-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0QSZ3_MYCS2

Accession

Primary (citable) accession number: A0QSZ3

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)