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Protein

Homoserine O-acetyltransferase

Gene

metXA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metXA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164NucleophileUniRule annotation1
Binding sitei234SubstrateUniRule annotation1
Active sitei327UniRule annotation1
Active sitei357UniRule annotation1
Binding sitei358SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074

Protein family/group databases

ESTHERimycs2-metx Homoserine_transacetylase

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXAUniRule annotation
Ordered Locus Names:MSMEG_1651, MSMEI_1613
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000218851 – 380Homoserine O-acetyltransferaseAdd BLAST380

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_1651

Structurei

3D structure databases

ProteinModelPortaliA0QSZ0
SMRiA0QSZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 363AB hydrolase-1UniRule annotationAdd BLAST305

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV Bacteria
COG2021 LUCA
HOGENOMiHOG000246301
KOiK00641
OMAiCQGTTGP
OrthoDBiPOG091H08NY

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
HAMAPiMF_00296 MetX_acyltransf, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR008220 HAT_MetX-like
PANTHERiPTHR32268 PTHR32268, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000443 Homoser_Ac_trans, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01392 homoserO_Ac_trn, 1 hit

Sequencei

Sequence statusi: Complete.

A0QSZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIIEERATD TGMATVPLPA EGEIGLVHIG ALTLENGTVL PDVTIAVQRW
60 70 80 90 100
GELAPDRGNV VMVLHALTGD SHVTGPAGDG HPTAGWWDGV AGPGAPIDTD
110 120 130 140 150
HWCAIATNVL GGCRGSTGPG SLAPDGKPWG SRFPQITIRD QVAADRAALA
160 170 180 190 200
ALGITEVAAV VGGSMGGARA LEWLVTHPDD VRAGLVLAVG ARATADQIGT
210 220 230 240 250
QSTQVAAIKA DPDWQGGDYH GTGRAPTEGM EIARRFAHLT YRGEEELDDR
260 270 280 290 300
FANTPQDDED PLTGGRYAVQ SYLEYQGGKL ARRFDPGTYV VLSDALSSHD
310 320 330 340 350
VGRGRGGVEA ALRSCPVPVV VGGITSDRLY PIRLQQELAE LLPGCQGLDV
360 370 380
VDSIYGHDGF LVETELVGKL IRRTLELAQR
Length:380
Mass (Da):39,954
Last modified:January 9, 2007 - v1
Checksum:i75EE16B2AEED6F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71400.1
CP001663 Genomic DNA Translation: AFP38085.1
RefSeqiWP_011727801.1, NZ_CP009494.1
YP_886028.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK71400; ABK71400; MSMEG_1651
AFP38085; AFP38085; MSMEI_1613
GeneIDi4533271
KEGGimsg:MSMEI_1613
msm:MSMEG_1651
PATRICifig|246196.19.peg.1636

Similar proteinsi

Entry informationi

Entry nameiMETXA_MYCS2
AccessioniPrimary (citable) accession number: A0QSZ0
Secondary accession number(s): I7F941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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