A0QSX1 (A0QSX1_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	MSMEG_1633

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK73772.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1095 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS023073
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0QSX1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 01C0C09E609AFC2A	FASTA	1,095	119,237
	10 20 30 40 50 60 MGWHNGPPSW SEMERVLTSK PRRSGLPLES PGDGGDSPAW SRKRGAYEPP DQARMPASAL 70 80 90 100 110 120 PYAELHAHSA YSFLDGASTP EELVEEAARL NLRAIALTDH DGLYGVVRFA EAARELDVAT 130 140 150 160 170 180 VFGAELSLSN VARTEDPDPP GPHLLVLARG PEGYRRLSRE IAKAHLAGGE KGRPRYDFDQ 190 200 210 220 230 240 LTEAAGGHWH ILTGCRKGHV RQALSDGGPD AAAAALADLV DRFGADRVSI ELTHHGHPCD 250 260 270 280 290 300 DERNAALAEL APRFGLGVVA TTAAHFATPS RGRLAMAMAA IRARNSIDTA AGWLAPLGGV 310 320 330 340 350 360 HLRSGEEMAR LFDPEFVAAA ADLGEQCAFG LALIAPQLPP FDVPDGHTED SWLRHLAMAG 370 380 390 400 410 420 AARRYGPPER APKAYAQIEH ELRIIEQLRF PGYFLVVHDI TQFCRDNNIL CQGRGSAANS 430 440 450 460 470 480 AVCYALGVTN VDPIANDLLF ERFLSPARDG PPDIDIDIES DLRENVIQYV YERYGRDYAA 490 500 510 520 530 540 QVANVITYRG RSAIRDMARA LGFSQGQQDA WSKHLSRWDG RPDSPDVAEI PEQVIELANQ 550 560 570 580 590 600 IANLPRHMGI HSGGMVICDR PIADVCPVEW ARMENRSVLQ WDKDDCAAIG LVKFDMLGLG 610 620 630 640 650 660 MLSALHYAID LVAEHKGIEV DLATLDLSEP AVYEMLQRAD SVGVFQVESR AQMATLPRLK 670 680 690 700 710 720 PREFYDLVVE VALIRPGPIQ GGSVHPYIKR RNGQEPVTYD HPSMEPALKK TLGVPLFQEQ 730 740 750 760 770 780 LMQLAVDCAG FSAAEADQLR RAMGSKRSTA KMRRLRSRFY DGMRERHGIT GVVADRIYEK 790 800 810 820 830 840 LEAFANFGFP ESHSLSFASL VFYSSWFKLH HPAAFCAALL RAQPMGFYSP QSLVADARRH 850 860 870 880 890 900 GVTVHGPDVN ASLAHAGLEN RGLDVRLGLG SVRHIGDDLA QRIVDEREAN GQFTSLLDLT 910 920 930 940 950 960 SRVQLTVPQT EALATAGALG CFGITRREGL WAAGAAATQR PDRLPGVGSS THIPPLPGMS 970 980 990 1000 1010 1020 ALELSAADVW ATGISPDSYP TEYLRKHLDS LGVVPTDRLL DVADGTRILV AGAVTHRQRP 1030 1040 1050 1060 1070 1080 ATAQGVTFIN LEDEKGMVNV LCAPGVWSRY RKVAQTAPAL IVRGIVQNAT GAVTVVADRM 1090 DAVNLRVGSR SRDFR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK73772.1.
RefSeq	YP_886009.1. NC_008596.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0QSX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000044935; EBMYCP00000043272; EBMYCG00000044930.
GeneID	4536540.
GenomeReviews	Gene locus MSMEG_1633 in contig CP000480_GR.
KEGG	msm:MSMEG_1633.
NMPDR	fig|246196.1.peg.1631.
PATRIC	18075721. VBIMycSme59918_1617.
TIGR	MSMEG_1633.
Phylogenomic databases
eggNOG	COG0587.
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0QSX1_MYCS2

Accession

Primary (citable) accession number: A0QSX1

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)