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Protein

60 kDa chaperonin 2

Gene

groL2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 2UniRule annotation
Alternative name(s):
GroEL protein 2UniRule annotation
Protein Cpn60 2UniRule annotation
Gene namesi
Name:groL2UniRule annotation
Synonyms:groEL2UniRule annotation, groL1
Ordered Locus Names:MSMEG_1583, MSMEI_1545
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

A0QSS4:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003320192 – 54060 kDa chaperonin 2Add BLAST539

Proteomic databases

PRIDEiA0QSS4.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_1583.

Structurei

3D structure databases

ProteinModelPortaliA0QSS4.
SMRiA0QSS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiYWIASNA.
OrthoDBiPOG091H00E7.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0QSS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQIEFNET ARRAMEAGVD KLADAVKVTL GPRGRHVVLA KSFGGPQVTN
60 70 80 90 100
DGVTIAREID LEDPYENLGA QLVKSVATKT NDVAGDGTTT ATVLAQALVR
110 120 130 140 150
AGLRNVAAGA NPIALGSGIS KAADAVSEAL LASATPVDDK KAIAQVATVS
160 170 180 190 200
SRDEQVGELV GEAMTKVGHD GVVTVEESST LETYLEVTEG VGFDKGFLSA
210 220 230 240 250
YFVTDFDSQE AVLEDALVLL HRDKISSLPD LLPLLEKVAE AGKPLLIVAE
260 270 280 290 300
DVEGEALSTL VVNAIRKTLK AVAVKAPFFG DRRKAFLDDL AIVTGGQVVN
310 320 330 340 350
PDVGLLLREV GLEVLGSARR VVVNKDSTVI VDGGGTAEAI ADRVKQIKSE
360 370 380 390 400
IETTDSDWDR EKLQERLAKL AGGVAVIKVG AATETDLKKR KEAVEDAVAA
410 420 430 440 450
AKAAVEEGIV TGGGAALVQA RSAVEKLRGE LSGDEALGVD VFASALSAPL
460 470 480 490 500
YWIATNAGLD GSVVVNKVSE LPKGQGFNAA TLEFGDLVSA GVVDPAKVTR
510 520 530 540
SAVLNAASVA RMILTTETAV VDKPADEDEH GHGHHHGHAH
Length:540
Mass (Da):56,153
Last modified:January 9, 2007 - v1
Checksum:i1486B7068102D546
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71399.1.
CP001663 Genomic DNA. Translation: AFP38018.1.
RefSeqiWP_011727753.1. NZ_CP009494.1.
YP_885962.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK71399; ABK71399; MSMEG_1583.
AFP38018; AFP38018; MSMEI_1545.
GeneIDi4533270.
KEGGimsb:LJ00_07905.
msg:MSMEI_1545.
msm:MSMEG_1583.
PATRICifig|246196.19.peg.1569.

Similar proteinsi

Entry informationi

Entry nameiCH602_MYCS2
AccessioniPrimary (citable) accession number: A0QSS4
Secondary accession number(s): I7FGN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families