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Protein

Glutamate decarboxylase

Gene

MSMEG_1574

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1574-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:MSMEG_1574Imported
ORF Names:LJ00_07860Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000029906 Componenti: Chromosome UP000000757 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1574.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QSR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKQSRGPH VAPAYTGRLA MAPVPSLRLP DEAMDPSAAY RFIHDELMLD
60 70 80 90 100
GSSRLNLATF VTTWMDPEAE KLMAETFDKN MIDKDEYPAT AAIEARCVSM
110 120 130 140 150
VADLFHAEDL RDDDPASAVG VSTIGSSEAV MLAGLAMKWR WRAKAGDWKG
160 170 180 190 200
RTPNLVMGAN VQVVWEKFCR YFDVEPRYLP MAEGRYVITP EQVLDAVDED
210 220 230 240 250
TIGVVAILGT TYTGELEPVA EICEALDKLA AGGGVDVPVH VDAASGGFVV
260 270 280 290 300
PFIHPDLVWD FRLPRVVSIN VSGHKYGLTY PGVGFVVWRN KEHLPEELVF
310 320 330 340 350
RVNYLGGDMP TFTLNFSRPG NQVVGQYYNF LRLGRAGYTQ VMQCLSQTAR
360 370 380 390 400
WLGDELRDSE HFELISDGSA IPVVAFRLKG DPGYTEFDIS QALRAHGWQV
410 420 430 440 450
PAYTMPEGAE DVVVLRVVVR EGFSADLARA LKDDIITVLG QLDALKPRGQ

FDQLQPFAH
Length:459
Mass (Da):50,768
Last modified:January 9, 2007 - v1
Checksum:i1AE0042D24A40797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75920.1.
CP009494 Genomic DNA. Translation: AIU06805.1.
RefSeqiWP_011727746.1. NC_008596.1.
YP_885953.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75920; ABK75920; MSMEG_1574.
AIU06805; AIU06805; LJ00_07860.
GeneIDi4537342.
KEGGimsm:MSMEG_1574.
PATRICi18075607. VBIMycSme59918_1560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75920.1.
CP009494 Genomic DNA. Translation: AIU06805.1.
RefSeqiWP_011727746.1. NC_008596.1.
YP_885953.1. NC_008596.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_1574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK75920; ABK75920; MSMEG_1574.
AIU06805; AIU06805; LJ00_07860.
GeneIDi4537342.
KEGGimsm:MSMEG_1574.
PATRICi18075607. VBIMycSme59918_1560.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1574-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  2. "Complete genome sequences of a Mycobacterium smegmatis laboratory strain (MC2 155) and isoniazid-resistant (4XR1/R2) mutant strains."
    Mohan A., Padiadpu J., Baloni P., Chandra N.
    Genome Announc. 3:E01520-E01520(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.

Entry informationi

Entry nameiA0QSR5_MYCS2
AccessioniPrimary (citable) accession number: A0QSR5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.