ID   A0QSN7_MYCS2            Unreviewed;       514 AA.
AC   A0QSN7;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Eptc-inducible aldehyde dehydrogenase {ECO:0000313|EMBL:ABK69777.1};
DE            EC=1.2.1.3 {ECO:0000313|EMBL:ABK69777.1};
GN   OrderedLocusNames=MSMEG_1543 {ECO:0000313|EMBL:ABK69777.1};
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK69777.1, ECO:0000313|Proteomes:UP000000757};
RN   [1] {ECO:0000313|EMBL:ABK69777.1, ECO:0000313|Proteomes:UP000000757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP000480; ABK69777.1; -; Genomic_DNA.
DR   RefSeq; YP_885925.1; NC_008596.1.
DR   AlphaFoldDB; A0QSN7; -.
DR   STRING; 246196.MSMEG_1543; -.
DR   PaxDb; 246196-MSMEI_1506; -.
DR   KEGG; msm:MSMEG_1543; -.
DR   PATRIC; fig|246196.19.peg.1528; -.
DR   eggNOG; COG1012; Bacteria.
DR   OrthoDB; 6882680at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   CDD; cd07116; ALDH_ACDHII-AcoD; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR43111; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   PANTHER; PTHR43111:SF1; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000757}.
FT   DOMAIN          35..501
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        270
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   514 AA;  55979 MW;  F161111EE532F580 CRC64;
     MSEQEKAMTV YARPGADGAK MSFQARYDNY IGGEWVAPVE GRYFENPTPV TGQVFCEVAR
     SSEADIDKAL DAAHAAAPAW GKTAPAERAL ILNRIADRME ENLESIALAE SWDNGKPIRE
     TLNADIPLAI DHFRYFAGVL RAQEGSLSQI DEDTVAYHFH EPLGVVGQII PWNFPILMAV
     WKLAPALAAG NAVVLKPAEQ TPVSVLYLFS LIGDLLPAGV VNIVNGFGVE AGKPLASSNR
     IAKIAFTGET TTGRLIMQYA SQNLIPVTLE LGGKSPNIFF NNVLAQADDY QDKALEGFTM
     FALNQGEVCT CPSRSLIQSD IFDEFLELAA IRTKAVRQGD PLDTETMIGA QASNDQLEKI
     LSYIEIGKSE GAKLITGGER AQLGGDLNGG YYVAPTIFTG NNKMRIFQEE IFGPVVAVTS
     FSDYDDAISI ANDTLYGLGA GVWSRDGNIA YRAGRDIKAG RVWTNCYHQY PAHAAFGGYK
     QSGIGRETHK MMLDHYQQTK NLLVSYSNKA QGFF
//