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Protein

Translation initiation factor IF-1

Gene

infA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor, RNA-binding, rRNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1UniRule annotation
Gene namesi
Name:infAUniRule annotation
Ordered Locus Names:MSMEG_1519, MSMEI_1483
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003388621 – 73Translation initiation factor IF-1Add BLAST73

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_1519

Structurei

3D structure databases

ProteinModelPortaliA0QSL3
SMRiA0QSL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73S1-likeUniRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the IF-1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K9U Bacteria
COG0361 LUCA
HOGENOMiHOG000221323
KOiK02518
OMAiAHVSGKM
OrthoDBiPOG091H019C

Family and domain databases

CDDicd04451 S1_IF1, 1 hit
HAMAPiMF_00075 IF_1, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR004368 TIF_IF1
PANTHERiPTHR33370 PTHR33370, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00008 infA, 1 hit
PROSITEiView protein in PROSITE
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A0QSL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKDGAIEV EGRVIEPLPN AMFRIELENG HKVLAHISGK MRQHYIRILP
60 70
EDRVVVELSP YDLSRGRIVY RYK
Length:73
Mass (Da):8,503
Last modified:January 9, 2007 - v1
Checksum:i70CEADB89E985B48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74732.1
CP001663 Genomic DNA Translation: AFP37956.1
RefSeqiWP_003886926.1, NZ_CP009494.1
YP_885901.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK74732; ABK74732; MSMEG_1519
AFP37956; AFP37956; MSMEI_1483
GeneIDi32363946
4532676
KEGGimsb:LJ00_07590
msg:MSMEI_1483
msm:MSMEG_1519
PATRICifig|246196.19.peg.1504

Similar proteinsi

Entry informationi

Entry nameiIF1_MYCS2
AccessioniPrimary (citable) accession number: A0QSL3
Secondary accession number(s): I7G467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 9, 2007
Last modified: February 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome