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Protein

50S ribosomal protein L1

Gene

rplA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.UniRule annotation
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L1UniRule annotation
Gene namesi
Name:rplAUniRule annotation
Ordered Locus Names:MSMEG_1347, MSMEI_1309
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 23523450S ribosomal protein L1PRO_0000308051Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_1347.

Structurei

3D structure databases

ProteinModelPortaliA0QS46.
SMRiA0QS46. Positions 6-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C64. Bacteria.
COG0081. LUCA.
HOGENOMiHOG000207015.
KOiK02863.
OMAiINAVQDY.
OrthoDBiPOG091H023J.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B. 1 hit.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0QS46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNSKAYRE AAEKVDRTKL YTPLEAAKLA KETSSKKQDA TVEVAIRLGV
60 70 80 90 100
DPRKADQMVR GTVNLPHGTG KTARVAVFAV GEKAEQAQAA GADIVGSDDL
110 120 130 140 150
IEKIQGGFLD FDAAIATPDQ MAKVGRIARV LGPRGLMPNP KTGTVTPDVA
160 170 180 190 200
KAVQDIKGGK INFRVDKQAN LHFIIGKASF DETKLAENYG AALDEVLRAK
210 220 230
PSSSKGRYLK KVTVSTTTGP GIPVDPSVTR NFTEA
Length:235
Mass (Da):25,020
Last modified:January 9, 2007 - v1
Checksum:iAE78B67C69479E01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75379.1.
CP001663 Genomic DNA. Translation: AFP37782.1.
RefSeqiWP_003892735.1. NZ_CP009494.1.
YP_885734.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75379; ABK75379; MSMEG_1347.
AFP37782; AFP37782; MSMEI_1309.
GeneIDi4533313.
KEGGimsb:LJ00_06715.
msg:MSMEI_1309.
msm:MSMEG_1347.
PATRICi18075149. VBIMycSme59918_1331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75379.1.
CP001663 Genomic DNA. Translation: AFP37782.1.
RefSeqiWP_003892735.1. NZ_CP009494.1.
YP_885734.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QS46.
SMRiA0QS46. Positions 6-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_1347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK75379; ABK75379; MSMEG_1347.
AFP37782; AFP37782; MSMEI_1309.
GeneIDi4533313.
KEGGimsb:LJ00_06715.
msg:MSMEI_1309.
msm:MSMEG_1347.
PATRICi18075149. VBIMycSme59918_1331.

Phylogenomic databases

eggNOGiENOG4105C64. Bacteria.
COG0081. LUCA.
HOGENOMiHOG000207015.
KOiK02863.
OMAiINAVQDY.
OrthoDBiPOG091H023J.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1347-MONOMER.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B. 1 hit.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL1_MYCS2
AccessioniPrimary (citable) accession number: A0QS46
Secondary accession number(s): I7FXZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.