ID   A0QRL4_MYCS2            Unreviewed;       475 AA.
AC   A0QRL4;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   SubName: Full=5-oxovalerate dehydrogenase {ECO:0000313|EMBL:ABK71275.1};
GN   OrderedLocusNames=MSMEG_1158 {ECO:0000313|EMBL:ABK71275.1};
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK71275.1, ECO:0000313|Proteomes:UP000000757};
RN   [1] {ECO:0000313|EMBL:ABK71275.1, ECO:0000313|Proteomes:UP000000757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP000480; ABK71275.1; -; Genomic_DNA.
DR   RefSeq; WP_011727459.1; NZ_SIJM01000011.1.
DR   RefSeq; YP_885552.1; NC_008596.1.
DR   AlphaFoldDB; A0QRL4; -.
DR   STRING; 246196.MSMEG_1158; -.
DR   PaxDb; 246196-MSMEI_1126; -.
DR   GeneID; 66732621; -.
DR   KEGG; msm:MSMEG_1158; -.
DR   PATRIC; fig|246196.19.peg.1151; -.
DR   eggNOG; COG1012; Bacteria.
DR   OrthoDB; 6882680at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000757}.
FT   DOMAIN          18..469
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        246
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   475 AA;  49696 MW;  EB02CBB8BDEAB5A1 CRC64;
     MTNAQNLIGG AWVGEPIIER RNPANPDDVV AIAPSASAAD VHDAVAAATD AQPGWAALTA
     VQRGAILMDA ADLLRRRHEE IATDLTREEG KTRAEAMGEV RRAIDVLRFF GSAGWRPSGE
     TLPSTMPNTS VHTRREPLGV VGLVTPWNFP IAIPAWKMAP ALVSGNAVVI KPAELTPLSI
     NHLATALIDA GLPAGVLNVV HGSGSLAGDA LVRHQEVAAV SFTGSTGVGM AIRDVVNARN
     ARVQLEMGGK NAYLVLDDAD VEAAAATVAA GAFSLTGQAC TATSRVYVTP GVREVFVKAL
     REKAGAVKSG NGLDPGTTMG PVVSDAQLAK DVTAIHAAVE AGFDAGEVTE PKGQFLAPVV
     FSGVPHDHPL VTREVFGPVV GVIDVADYQE GLNLVNDSPY GLTAGICTRD LGKAYDFAAR
     VRVGVVKINR PTTGLDLNVP FGGVRDSSTN TFREQGERAV DFYTWTKSVY IGHDL
//