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Protein

Protease HtpX homolog

Gene

htpX

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi135 – 1351Zinc; catalyticUniRule annotation
Active sitei136 – 1361UniRule annotation
Metal bindingi139 – 1391Zinc; catalyticUniRule annotation
Metal bindingi206 – 2061Zinc; catalyticUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1134-MONOMER.

Protein family/group databases

MEROPSiM48.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease HtpX homologUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:htpXUniRule annotation
Ordered Locus Names:MSMEG_1134, MSMEI_1102
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalUniRule annotationAdd
BLAST
Transmembranei33 – 5321HelicalUniRule annotationAdd
BLAST
Transmembranei145 – 16521HelicalUniRule annotationAdd
BLAST
Transmembranei181 – 20121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Protease HtpX homologPRO_1000020889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1134.

Structurei

3D structure databases

ProteinModelPortaliA0QRJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D0M. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000227301.
KOiK03799.
OMAiYAYWNSD.
OrthoDBiEOG6F55J5.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX.
InterProiIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QRJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWNPHANRL KTFLLLVGMS GLIVFVGSLF GRNVMFLAVL FAVGMNAYVY
60 70 80 90 100
FNSDKLALRA MHAQPITEVQ APEIYRIVRE LATTAHQPMP RLYISDTANP
110 120 130 140 150
NAFATGRNPR NAAVCCTTGI LQLLNERELR AVLGHELSHV YNRDILISCV
160 170 180 190 200
AGAMASVITA LANMAMFAGM FGGNREGGNP LALLLVSFLG PIAATVVKLA
210 220 230 240 250
VSRSREYQAD QSGAELTGDP LALASALRKI SGGVEAAPLP PQPQLADQAH
260 270 280 290
LMIASPFRAG ERIGKLFSTH PPIADRIRRL EDMAGRGGSR PDSYY
Length:295
Mass (Da):31,829
Last modified:January 9, 2007 - v1
Checksum:iACA7115CB7FCCAC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73166.1.
CP001663 Genomic DNA. Translation: AFP37580.1.
RefSeqiWP_011727439.1. NZ_CP009494.1.
YP_885528.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK73166; ABK73166; MSMEG_1134.
AFP37580; AFP37580; MSMEI_1102.
GeneIDi4531903.
KEGGimsb:LJ00_05645.
msg:MSMEI_1102.
msm:MSMEG_1134.
PATRICi18074731. VBIMycSme59918_1126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73166.1.
CP001663 Genomic DNA. Translation: AFP37580.1.
RefSeqiWP_011727439.1. NZ_CP009494.1.
YP_885528.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QRJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_1134.

Protein family/group databases

MEROPSiM48.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK73166; ABK73166; MSMEG_1134.
AFP37580; AFP37580; MSMEI_1102.
GeneIDi4531903.
KEGGimsb:LJ00_05645.
msg:MSMEI_1102.
msm:MSMEG_1134.
PATRICi18074731. VBIMycSme59918_1126.

Phylogenomic databases

eggNOGiENOG4105D0M. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000227301.
KOiK03799.
OMAiYAYWNSD.
OrthoDBiEOG6F55J5.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1134-MONOMER.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX.
InterProiIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.

Entry informationi

Entry nameiHTPX_MYCS2
AccessioniPrimary (citable) accession number: A0QRJ0
Secondary accession number(s): I7F7N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.