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Protein

GDP-mannose-dependent alpha-mannosyltransferase

Gene

mgtA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the addition of a mannose residue from GDP-D-mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-glycerol(ManGlcAGroAc2).By similarity

Pathwayi: phosphatidylinositol metabolism

This protein is involved in the pathway phosphatidylinositol metabolism, which is part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol metabolism and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism, Virulence

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1112-MONOMER.
UniPathwayiUPA00949.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-mannose-dependent alpha-mannosyltransferase (EC:2.4.1.-)
Alternative name(s):
Guanosine diphosphomannose-dependent alpha-mannosyltransferase
Gene namesi
Name:mgtA
Synonyms:pimB
Ordered Locus Names:MSMEG_1113, MSMEI_1080
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375GDP-mannose-dependent alpha-mannosyltransferasePRO_0000393731Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1113.

Structurei

3D structure databases

ProteinModelPortaliA0QRG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0438. LUCA.
HOGENOMiHOG000077285.
KOiK12583.
OMAiWQRGVDT.
OrthoDBiEOG68DD0W.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QRG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAIVAESF LPNVNGVTNS VLRVIDHLRR TGHEVLVIAP DTPRGQPPAD
60 70 80 90 100
RIHDGVRVHR VPSRMFPKIT SLPLGVPRPR MIGVLRGFDP DVVHLASPAL
110 120 130 140 150
LGYGGLHAAR HLGVPSVAVF QTDVAGFAES YGMGVASRAA WAWTRHLHSR
160 170 180 190 200
ADRTLAPSTS AMENLAAHRI PRVHRWGRGV DITGFVPSAR DEHLRRTWSP
210 220 230 240 250
DGRPIVGFVG RLAPEKHVER LAVLAARDDL QLVIVGDGVD RVKLQTVLPT
260 270 280 290 300
AVFTGELRGA ALAAAYASMD VFVHPGEHET FCQTVQEAMA SGVPVIAPDA
310 320 330 340 350
GGPRDLVAPC RTGLLLDVDG FECALPAAVT HLIAERRRYG IAARRSVLAR
360 370
TWPVVCDELI GHYEAVLGRR SLRAA
Length:375
Mass (Da):40,565
Last modified:January 9, 2007 - v1
Checksum:i62410854271FD7C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71357.1.
CP001663 Genomic DNA. Translation: AFP37560.1.
RefSeqiWP_011727419.1. NZ_CP009494.1.
YP_885506.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK71357; ABK71357; MSMEG_1113.
AFP37560; AFP37560; MSMEI_1080.
GeneIDi4534281.
KEGGimsb:LJ00_05530.
msg:MSMEI_1080.
msm:MSMEG_1113.
PATRICi18074681. VBIMycSme59918_1101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71357.1.
CP001663 Genomic DNA. Translation: AFP37560.1.
RefSeqiWP_011727419.1. NZ_CP009494.1.
YP_885506.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QRG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_1113.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK71357; ABK71357; MSMEG_1113.
AFP37560; AFP37560; MSMEI_1080.
GeneIDi4534281.
KEGGimsb:LJ00_05530.
msg:MSMEI_1080.
msm:MSMEG_1113.
PATRICi18074681. VBIMycSme59918_1101.

Phylogenomic databases

eggNOGiCOG0438. LUCA.
HOGENOMiHOG000077285.
KOiK12583.
OMAiWQRGVDT.
OrthoDBiEOG68DD0W.

Enzyme and pathway databases

UniPathwayiUPA00949.
BioCyciMSME246196:GJ4Y-1112-MONOMER.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.

Entry informationi

Entry nameiMGTA_MYCS2
AccessioniPrimary (citable) accession number: A0QRG8
Secondary accession number(s): I7F7L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 9, 2007
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.