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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei110Proton donorUniRule annotation1
Metal bindingi138MagnesiumUniRule annotation1
Metal bindingi165MagnesiumUniRule annotation1
Metal bindingi188MagnesiumUniRule annotation1
Active sitei212Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMenaquinone biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00079
UPA01057; UER00165

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotation (EC:4.2.1.113UniRule annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:MSMEG_1103, MSMEI_1070
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000138051 – 321o-succinylbenzoate synthaseAdd BLAST321

Proteomic databases

PRIDEiA0QRG0

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1103

Structurei

3D structure databases

ProteinModelPortaliA0QRG0
SMRiA0QRG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TCW Bacteria
COG4948 LUCA
HOGENOMiHOG000249513
KOiK02549
OMAiAGWGEFS
OrthoDBiPOG091H04PO

Family and domain databases

Gene3Di3.20.20.120, 1 hit
3.30.390.10, 2 hits
HAMAPiMF_00470 MenC_1, 1 hit
InterProiView protein in InterPro
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR029065 Enolase_C-like
IPR013342 Mandelate_racemase_C
IPR010196 OSB_synthase_MenC1
PfamiView protein in Pfam
PF13378 MR_MLE_C, 1 hit
SMARTiView protein in SMART
SM00922 MR_MLE, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit

Sequencei

Sequence statusi: Complete.

A0QRG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNGVPALDD ILERLHVVAL PMRVRFRGIT VRELALIDGP AGWGEFGAFV
60 70 80 90 100
EYEPPEAAAW LSSALEAAYR PAPAALRDRV PINATVPAVS AERVPEVLAR
110 120 130 140 150
FPGARTAKVK VAEPGQSLAD DVARVNAVRE SVPVVRVDAN GGWSVDDAVE
160 170 180 190 200
AAAALTADGE LEYLEQPCAT VEELAALRAR VDVPIAADES IRKAEDPLRV
210 220 230 240 250
VRAHAADIAV LKVAPLGGVA RMLDIAAQID IPIVVSSALD SSVGIGRGLL
260 270 280 290 300
AAAALPELRH ACGLGTGGLF VDDVAEPRVP VDGCLAVEPA VPDPARLAAL
310 320
AAPEPRRQWW IDRVCACHAL I
Length:321
Mass (Da):33,686
Last modified:January 9, 2007 - v1
Checksum:i6AF928062C42A812
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74303.1
CP001663 Genomic DNA Translation: AFP37550.1
RefSeqiWP_011727412.1, NZ_CP009494.1
YP_885498.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK74303; ABK74303; MSMEG_1103
AFP37550; AFP37550; MSMEI_1070
GeneIDi4532162
KEGGimsb:LJ00_05485
msg:MSMEI_1070
msm:MSMEG_1103
PATRICifig|246196.19.peg.1091

Similar proteinsi

Entry informationi

Entry nameiMENC_MYCS2
AccessioniPrimary (citable) accession number: A0QRG0
Secondary accession number(s): I7F7K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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