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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC), o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101Proton donorUniRule annotation
Metal bindingi138 – 1381MagnesiumUniRule annotation
Metal bindingi165 – 1651MagnesiumUniRule annotation
Metal bindingi188 – 1881MagnesiumUniRule annotation
Active sitei212 – 2121Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-1103-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00165.

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotation (EC:4.2.1.113UniRule annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:MSMEG_1103, MSMEI_1070
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321o-succinylbenzoate synthasePRO_1000013805Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1103.

Structurei

3D structure databases

ProteinModelPortaliA0QRG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TCW. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000249513.
KOiK02549.
OMAiYAEQPCA.
OrthoDBiPOG091H04PO.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00470. MenC_1. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR001354. MR/MLE/MAL.
IPR010196. OSB_synthase_MenC1.
IPR010197. OSB_synthase_MenC_2.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QRG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNGVPALDD ILERLHVVAL PMRVRFRGIT VRELALIDGP AGWGEFGAFV
60 70 80 90 100
EYEPPEAAAW LSSALEAAYR PAPAALRDRV PINATVPAVS AERVPEVLAR
110 120 130 140 150
FPGARTAKVK VAEPGQSLAD DVARVNAVRE SVPVVRVDAN GGWSVDDAVE
160 170 180 190 200
AAAALTADGE LEYLEQPCAT VEELAALRAR VDVPIAADES IRKAEDPLRV
210 220 230 240 250
VRAHAADIAV LKVAPLGGVA RMLDIAAQID IPIVVSSALD SSVGIGRGLL
260 270 280 290 300
AAAALPELRH ACGLGTGGLF VDDVAEPRVP VDGCLAVEPA VPDPARLAAL
310 320
AAPEPRRQWW IDRVCACHAL I
Length:321
Mass (Da):33,686
Last modified:January 9, 2007 - v1
Checksum:i6AF928062C42A812
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74303.1.
CP001663 Genomic DNA. Translation: AFP37550.1.
RefSeqiWP_011727412.1. NZ_CP009494.1.
YP_885498.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74303; ABK74303; MSMEG_1103.
AFP37550; AFP37550; MSMEI_1070.
GeneIDi4532162.
KEGGimsb:LJ00_05485.
msg:MSMEI_1070.
msm:MSMEG_1103.
PATRICi18074660. VBIMycSme59918_1091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74303.1.
CP001663 Genomic DNA. Translation: AFP37550.1.
RefSeqiWP_011727412.1. NZ_CP009494.1.
YP_885498.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QRG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_1103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74303; ABK74303; MSMEG_1103.
AFP37550; AFP37550; MSMEI_1070.
GeneIDi4532162.
KEGGimsb:LJ00_05485.
msg:MSMEI_1070.
msm:MSMEG_1103.
PATRICi18074660. VBIMycSme59918_1091.

Phylogenomic databases

eggNOGiENOG4107TCW. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000249513.
KOiK02549.
OMAiYAEQPCA.
OrthoDBiPOG091H04PO.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.
BioCyciMSME246196:GJ4Y-1103-MONOMER.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00470. MenC_1. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR001354. MR/MLE/MAL.
IPR010196. OSB_synthase_MenC1.
IPR010197. OSB_synthase_MenC_2.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMENC_MYCS2
AccessioniPrimary (citable) accession number: A0QRG0
Secondary accession number(s): I7F7K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.