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Protein

1,4-dihydroxy-2-naphthoyl-CoA synthase

Gene

menB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).UniRule annotation1 Publication

Catalytic activityi

4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O.UniRule annotation1 Publication

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Sitei110Important for catalysisUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Sitei180Important for catalysisUniRule annotation1
Binding sitei185SubstrateUniRule annotation1
Binding sitei282Substrate; shared with neighboring subunitUniRule annotation1
Sitei282Important for catalysisUniRule annotation1
Binding sitei297Substrate; shared with neighboring subunitUniRule annotation1

GO - Molecular functioni

  • 1,4-dihydroxy-2-naphthoyl-CoA synthase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMenaquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00079
UPA01057; UER00167

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoyl-CoA synthaseUniRule annotation (EC:4.1.3.36UniRule annotation)
Short name:
DHNA-CoA synthaseUniRule annotation
Gene namesi
Name:menBUniRule annotation
Ordered Locus Names:MSMEG_1075, MSMEI_1042
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004031871 – 3091,4-dihydroxy-2-naphthoyl-CoA synthaseAdd BLAST309

Proteomic databases

PRIDEiA0QRD3

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_1075

Structurei

3D structure databases

ProteinModelPortaliA0QRD3
SMRiA0QRD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 102Substrate bindingUniRule annotation5
Regioni152 – 156Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SIQ Bacteria
COG0447 LUCA
HOGENOMiHOG000027942
KOiK01661
OMAiHSLHVVA
OrthoDBiPOG091H05HP

Family and domain databases

Gene3Di1.10.12.10, 1 hit
HAMAPiMF_01934 MenB, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR010198 DHNA-CoA_synthase_MenB
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 enoyl-CoA_hydra_C
PANTHERiPTHR43113 PTHR43113, 1 hit
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR01929 menB, 1 hit

Sequencei

Sequence statusi: Complete.

A0QRD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQAASDNP FDPAMWERVP GFDDLTDITY HRHVLDGARQ PTVRVAFDRP
60 70 80 90 100
EVRNAFRPHT VDELYRVLDH ARMSSDVGVI LLTGNGPSPK DGGWAFCSGG
110 120 130 140 150
DQRIRGRTGY QYASGETAET VDPARAGRLH ILEVQRLIRF MPKVVICLVN
160 170 180 190 200
GWAAGGGHSL HVTCDLTLAS REHARFKQTD ADVGSFDGGF GSAYLARQTG
210 220 230 240 250
QKFAREIFFL GRAYDAQTMH QMGAVNEVVD HADLEKAGLQ YAAEINGKSP
260 270 280 290 300
QAIRMLKFAF NLIDDGLVGQ QVFAGEATRL AYMTDEAVEG RDAFLEKRDP

DWSRFPRYF
Length:309
Mass (Da):34,303
Last modified:January 9, 2007 - v1
Checksum:iCACC8113C74964B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74961.1
CP001663 Genomic DNA Translation: AFP37522.1
RefSeqiWP_003892442.1, NZ_CP009494.1
YP_885471.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK74961; ABK74961; MSMEG_1075
AFP37522; AFP37522; MSMEI_1042
GeneIDi4531869
KEGGimsb:LJ00_05340
msg:MSMEI_1042
msm:MSMEG_1075
PATRICifig|246196.19.peg.1062

Similar proteinsi

Entry informationi

Entry nameiMENB_MYCS2
AccessioniPrimary (citable) accession number: A0QRD3
Secondary accession number(s): I7FXI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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