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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:MSMEG_0969, MSMEI_0943
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003823461 – 451Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA0QR33

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_0969

Structurei

3D structure databases

ProteinModelPortaliA0QR33
SMRiA0QR33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0QR33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRVDQTCG SEEHSPASTQ RSAQLFADAC AVIPGGVNSP VRAFNSVGGT
60 70 80 90 100
PRFITSAGGY WLTDADGNRY IDLVCSWGPM LLGHAHPAVV EAVRKVAEHG
110 120 130 140 150
LSFGAPTPSE TELAAEIIDR VAPVEMMRFV NSGTEATMSA IRLARGFTGR
160 170 180 190 200
AKIVKFSGCY HGHSDALLAD AGSGVATLGL PSSPGVTGAA AADTIVIPYN
210 220 230 240 250
NVAAVEDVFA HFGDEIACVI SEASPGNMGT VPPLPGFNAA LRRITAEHGA
260 270 280 290 300
LLILDEVMTG FRVSRSGWYG LDPVEADLLT FGKVMSGGLP AAAFGGRTEV
310 320 330 340 350
MSRLAPLGPV YQAGTLSGNP VAMAAGLTTL RHADDAVYAK LDANADRLAG
360 370 380 390 400
LLTGALTEAG VAHQVQRAGN MLSVFFTDAP VHDFAAAKAT ETWRFPPFFH
410 420 430 440 450
ALLERGVYPP CSAFETWFVS AALDDDAFAR IAEALPAAAR AAAAATPEGT

A
Length:451
Mass (Da):46,772
Last modified:January 9, 2007 - v1
Checksum:iB9E292D5BED609A2
GO

Sequence cautioni

The sequence AFP37423 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK75419.1
CP001663 Genomic DNA Translation: AFP37423.1 Different initiation.
RefSeqiWP_011727321.1, NZ_CP009494.1
YP_885371.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK75419; ABK75419; MSMEG_0969
AFP37423; AFP37423; MSMEI_0943
GeneIDi4536923
KEGGimsg:MSMEI_0943
msm:MSMEG_0969
PATRICifig|246196.19.peg.957

Similar proteinsi

Entry informationi

Entry nameiGSA_MYCS2
AccessioniPrimary (citable) accession number: A0QR33
Secondary accession number(s): I7FEZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: January 9, 2007
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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