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Protein

Pyrroline-5-carboxylate reductase

Gene

proC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.UniRule annotation

Catalytic activityi

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pyrroline-5-carboxylate reductase (proC), Pyrroline-5-carboxylate reductase (proC)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Proline biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00098; UER00361.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroline-5-carboxylate reductaseUniRule annotation (EC:1.5.1.2UniRule annotation)
Short name:
p5C reductaseUniRule annotation
Short name:
p5CRUniRule annotation
Alternative name(s):
PCA reductaseUniRule annotation
Gene namesi
Name:proCUniRule annotationImported
Ordered Locus Names:MSMEG_0943Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0943.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyrroline-5-carboxylate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105II7. Bacteria.
COG0345. LUCA.
HOGENOMiHOG000230247.
KOiK00286.
OMAiRVMTNTP.
OrthoDBiPOG091H02KJ.

Family and domain databases

HAMAPiMF_01925. P5C_reductase. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH-like_C_sf.
IPR036291. NAD(P)-bd_dom_sf.
IPR028939. P5C_Rdtase_cat_N.
IPR029036. P5CR_dimer.
IPR000304. Pyrroline-COOH_reductase.
PfamiView protein in Pfam
PF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
PIRSFiPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00112. proC. 1 hit.
PROSITEiView protein in PROSITE
PS00521. P5CR. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QR08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIAIIGGG SMGEALLSGL LRAGRQVKDM VVAEKFPERA KYLADKYSVR
60 70 80 90 100
VTSVADAAEN AHYVVVAVKP ADVEKVIGEI AEAAANAETD TAEQVFVTIA
110 120 130 140 150
AGVGTAYYEA KLPAGSPVIR VMPNAPVIVG GGVSALAPGR FATPEQLKEV
160 170 180 190 200
STLFDAVGGV ITVSESQLDA VTALSGSGPA YFFLMAEAMV DAGVAVGLSR
210 220 230 240 250
AVATDLVAQT MAGSAAMLLD RLDQVNAAGG AALDTTPAQL RATVTSPAGT
260 270 280
TAAGLRELER GGLRAAVANA VEAAKTRSEQ LGITSE
Length:286
Mass (Da):28,989
Last modified:January 9, 2007 - v1
Checksum:i8D33671128B4AE75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74403.1.
RefSeqiWP_011727304.1. NZ_CP009494.1.
YP_885346.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74403; ABK74403; MSMEG_0943.
AFP37400; AFP37400; MSMEI_0920.
GeneIDi4531470.
KEGGimsb:LJ00_04680.
msm:MSMEG_0943.
PATRICifig|246196.19.peg.933.

Similar proteinsi

Entry informationi

Entry nameiA0QR08_MYCS2
AccessioniPrimary (citable) accession number: A0QR08
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported