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Protein

Signal-transduction histidine kinase senX3

Gene

senX3

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the two-component regulatory system senX3/regX3. Phosphorylates regX3 under conditions of phosphate limitation. Probably does not itself sense phosphate concentrations, which may be relayed to senX3 by the PstSCAB phosphate transporter system.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-transduction histidine kinase senX3 (EC:2.7.13.3)
Gene namesi
Name:senX3
Ordered Locus Names:MSMEG_0936, MSMEI_0913
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003574721 – 384Signal-transduction histidine kinase senX3Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By phosphate-limiting growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0936.

Structurei

3D structure databases

ProteinModelPortaliA0QR01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 369Histidine kinasePROSITE-ProRule annotationAdd BLAST217

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000223176.
KOiK07768.
OMAiRISTEWT.
OrthoDBiPOG091H02OU.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QR01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLTLIAGV AVGVTVVPRI VARRQRRAAY AAGMTVSQML QHITSLSPMG
60 70 80 90 100
VAVVDTFNDV VYSNDRAVEL NVVRDRILDD RAWQAAQRVF ETGQDVEVDL
110 120 130 140 150
SPLKVANPGR SGISVRGKVR LLTDDDRRFA VVYIDDQSEH ARMEATRRDF
160 170 180 190 200
VANVSHELKT PVGAMSVLAE ALLASADDPD TVRRFAEKMV AESHRLADMI
210 220 230 240 250
GELIELSRLQ GAERLPDLDA VDVDSIVSEA VSRHKVAADN SQISITTDAP
260 270 280 290 300
TGYRVLGDEG LLVTAIANLV SNAIAYSPNG TDVSISRRKR GGNIEIAVTD
310 320 330 340 350
RGIGIAKDDQ ERVFERFFRV DKARSRATGG TGLGLAIVKH VAANHNGSIR
360 370 380
LWSQPGTGST FTLSIPEYPD PESHSDERED QRER
Length:384
Mass (Da):41,862
Last modified:January 9, 2007 - v1
Checksum:iDFE8034CA4086F24
GO

Sequence cautioni

The sequence AFP37393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74063.1.
CP001663 Genomic DNA. Translation: AFP37393.1. Different initiation.
RefSeqiWP_011727297.1. NC_008596.1.
WP_014876913.1. NZ_CP009494.1.
YP_885339.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74063; ABK74063; MSMEG_0936.
AFP37393; AFP37393; MSMEI_0913.
GeneIDi4536256.
KEGGimsg:MSMEI_0913.
msm:MSMEG_0936.
PATRICi18074330. VBIMycSme59918_0926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74063.1.
CP001663 Genomic DNA. Translation: AFP37393.1. Different initiation.
RefSeqiWP_011727297.1. NC_008596.1.
WP_014876913.1. NZ_CP009494.1.
YP_885339.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QR01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_0936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74063; ABK74063; MSMEG_0936.
AFP37393; AFP37393; MSMEI_0913.
GeneIDi4536256.
KEGGimsg:MSMEI_0913.
msm:MSMEG_0936.
PATRICi18074330. VBIMycSme59918_0926.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000223176.
KOiK07768.
OMAiRISTEWT.
OrthoDBiPOG091H02OU.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSENX3_MYCS2
AccessioniPrimary (citable) accession number: A0QR01
Secondary accession number(s): I7FEW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.