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A0QQS6 (PSD_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MSMEG_0861
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Phosphatidylserine decarboxylase beta chain By similarity
PRO_1000026654
Chain201 – 23232Phosphatidylserine decarboxylase alpha chain By similarity
PRO_1000026655

Sites

Site200 – 2012Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2011Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QQS6 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 81D156462804B115

FASTA23224,817
        10         20         30         40         50         60 
MARRPDLQSG PERLAALVRS SIPPMHSAGL PFVGASLAVA LLGRKRRWMR RAGLISAGAN 

        70         80         90        100        110        120 
AAFFRHPPRV PPTRPGVVVA PADGLICLLG EATPPAELGL PDIPMQRVSI FLSVLDAHVQ 

       130        140        150        160        170        180 
RAPIGGEVVA VRHRPGRFHS AELEAASEDN ERNSVVIRTP EGLHIIAVQI AGLIARRIVC 

       190        200        210        220        230 
DVHVGDKLSI GDTYGLIRYG SRLDTYFPAD ARVLVSHGQR TLAGETVLAE LA

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK75810.1.
RefSeqYP_885264.1. NC_008596.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0QQS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000044034; EBMYCP00000042371; EBMYCG00000044029.
GeneID4531023.
GenomeReviewsGene locus MSMEG_0861 in contig CP000480_GR.
KEGGmsm:MSMEG_0861.
NMPDRfig|246196.1.peg.854.
PATRIC18074182. VBIMycSme59918_0852.
TIGRMSMEG_0861.

Phylogenomic databases

eggNOGCOG0688.
GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycMSME246196:MSMEG_0861-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCS2
AccessionPrimary (citable) accession number: A0QQS6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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