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Protein

Putative glutamate--cysteine ligase 2-1

Gene

MSMEG_0836

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutamate--cysteine ligase 2-1UniRule annotation (EC:6.3.2.2UniRule annotation)
Alternative name(s):
Gamma-glutamylcysteine synthetase 2-1UniRule annotation
Short name:
GCS 2-1UniRule annotation
Short name:
Gamma-GCS 2-1UniRule annotation
Gene namesi
Ordered Locus Names:MSMEG_0836, MSMEI_0817
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Putative glutamate--cysteine ligase 2-1PRO_0000323505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0836.

Structurei

3D structure databases

ProteinModelPortaliA0QQQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106KXD. Bacteria.
COG2170. LUCA.
HOGENOMiHOG000220943.
KOiK06048.
OMAiAFPMSGR.
OrthoDBiPOG091H09O7.

Family and domain databases

HAMAPiMF_01609. Glu_cys_ligase_2. 1 hit.
InterProiIPR006336. GCS2.
IPR011793. YbdK.
[Graphical view]
PfamiPF04107. GCS2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02050. gshA_cyan_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QQQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPADSRI DFAGSPRPTV GVEWEFALVD AKTRELSNEA AAVIAEIGEN
60 70 80 90 100
PHVHKELLRN TVEIVTGICE NSGEAMGDLC DTLSTVRRAV RGRGMELFCA
110 120 130 140 150
GTHPFGKWSA AQLTDAPRYA ELIKRTQWWG RQMLIWGVHV HVGVSSAHKV
160 170 180 190 200
MPIISSLLNQ YPHLLALSAS SPFWDGEDTG YASNRAMMFQ QLPTAGLPFQ
210 220 230 240 250
FQTWHEFEGF VHDQKKTGII DHLSEIRWDI RPSPQLGTVE VRIFDGVSNV
260 270 280 290 300
RELSALVALT HCLIVDLDRR LDAGEQLPVM PPWHVQENKW RAARYGLDAV
310 320 330 340 350
IILDADSNER LVTEDLDDLL NHLEPVAASL HCADELAAVE DIYRLGGSYQ
360 370
RQRRVAEEND GDLREVVDAL IGELEL
Length:376
Mass (Da):41,970
Last modified:January 9, 2007 - v1
Checksum:i9AAEDD951D4A1F90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73867.1.
CP001663 Genomic DNA. Translation: AFP37297.1.
RefSeqiWP_003892265.1. NZ_CP009494.1.
YP_885240.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK73867; ABK73867; MSMEG_0836.
AFP37297; AFP37297; MSMEI_0817.
GeneIDi4536446.
KEGGimsb:LJ00_04160.
msg:MSMEI_0817.
msm:MSMEG_0836.
PATRICi18074136. VBIMycSme59918_0829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73867.1.
CP001663 Genomic DNA. Translation: AFP37297.1.
RefSeqiWP_003892265.1. NZ_CP009494.1.
YP_885240.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QQQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_0836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK73867; ABK73867; MSMEG_0836.
AFP37297; AFP37297; MSMEI_0817.
GeneIDi4536446.
KEGGimsb:LJ00_04160.
msg:MSMEI_0817.
msm:MSMEG_0836.
PATRICi18074136. VBIMycSme59918_0829.

Phylogenomic databases

eggNOGiENOG4106KXD. Bacteria.
COG2170. LUCA.
HOGENOMiHOG000220943.
KOiK06048.
OMAiAFPMSGR.
OrthoDBiPOG091H09O7.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-836-MONOMER.

Family and domain databases

HAMAPiMF_01609. Glu_cys_ligase_2. 1 hit.
InterProiIPR006336. GCS2.
IPR011793. YbdK.
[Graphical view]
PfamiPF04107. GCS2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02050. gshA_cyan_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCS21_MYCS2
AccessioniPrimary (citable) accession number: A0QQQ2
Secondary accession number(s): I7FX34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.