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Protein

Putative glutamate--cysteine ligase 2-1

Gene

MSMEG_0836

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutamate--cysteine ligase 2-1UniRule annotation (EC:6.3.2.2UniRule annotation)
Alternative name(s):
Gamma-glutamylcysteine synthetase 2-1UniRule annotation
Short name:
GCS 2-1UniRule annotation
Short name:
Gamma-GCS 2-1UniRule annotation
Gene namesi
Ordered Locus Names:MSMEG_0836, MSMEI_0817
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235051 – 376Putative glutamate--cysteine ligase 2-1Add BLAST376

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0836

Structurei

3D structure databases

ProteinModelPortaliA0QQQ2
SMRiA0QQQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106KXD Bacteria
COG2170 LUCA
HOGENOMiHOG000220943
KOiK06048
OMAiLDENKWR
OrthoDBiPOG091H09O7

Family and domain databases

HAMAPiMF_01609 Glu_cys_ligase_2, 1 hit
InterProiView protein in InterPro
IPR006336 GCS2
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR011793 YbdK
PfamiView protein in Pfam
PF04107 GCS2, 1 hit
SUPFAMiSSF55931 SSF55931, 1 hit
TIGRFAMsiTIGR02050 gshA_cyan_rel, 1 hit

Sequencei

Sequence statusi: Complete.

A0QQQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPADSRI DFAGSPRPTV GVEWEFALVD AKTRELSNEA AAVIAEIGEN
60 70 80 90 100
PHVHKELLRN TVEIVTGICE NSGEAMGDLC DTLSTVRRAV RGRGMELFCA
110 120 130 140 150
GTHPFGKWSA AQLTDAPRYA ELIKRTQWWG RQMLIWGVHV HVGVSSAHKV
160 170 180 190 200
MPIISSLLNQ YPHLLALSAS SPFWDGEDTG YASNRAMMFQ QLPTAGLPFQ
210 220 230 240 250
FQTWHEFEGF VHDQKKTGII DHLSEIRWDI RPSPQLGTVE VRIFDGVSNV
260 270 280 290 300
RELSALVALT HCLIVDLDRR LDAGEQLPVM PPWHVQENKW RAARYGLDAV
310 320 330 340 350
IILDADSNER LVTEDLDDLL NHLEPVAASL HCADELAAVE DIYRLGGSYQ
360 370
RQRRVAEEND GDLREVVDAL IGELEL
Length:376
Mass (Da):41,970
Last modified:January 9, 2007 - v1
Checksum:i9AAEDD951D4A1F90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73867.1
CP001663 Genomic DNA Translation: AFP37297.1
RefSeqiWP_003892265.1, NZ_CP009494.1
YP_885240.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK73867; ABK73867; MSMEG_0836
AFP37297; AFP37297; MSMEI_0817
GeneIDi4536446
KEGGimsb:LJ00_04160
msg:MSMEI_0817
msm:MSMEG_0836
PATRICifig|246196.19.peg.829

Similar proteinsi

Entry informationi

Entry nameiGCS21_MYCS2
AccessioniPrimary (citable) accession number: A0QQQ2
Secondary accession number(s): I7FX34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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