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Protein

Peptide deformylase

Gene

def

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi106IronUniRule annotation1
Metal bindingi148IronUniRule annotation1
Active sitei149UniRule annotation1
Metal bindingi152IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:MSMEG_0832, MSMEI_0813
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003010591 – 197Peptide deformylaseAdd BLAST197

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0832

Structurei

3D structure databases

ProteinModelPortaliA0QQP8
SMRiA0QQP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
KOiK01462
OMAiVCIQHEI
OrthoDBiPOG091H02B0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

A0QQP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVPIRIVG DPVLHTPTEP VPVGPDGSLP DDLPALIQDM FDTMDAANGV
60 70 80 90 100
GLAANQIGVA KRLFVYDCAP TRGQTTRRRG VVINPVLETS EVPETMPDPD
110 120 130 140 150
EDEEGCLSVP GENFPTGRAD WARVTGLDAD GSPITLEGED LFARMLQHET
160 170 180 190
GHLDGFLYLD RLVGRYARAA KKAVKRNGWG VPGLSWMPGE VPDPFGH
Length:197
Mass (Da):21,208
Last modified:January 9, 2007 - v1
Checksum:i6305E1E7B6598980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72853.1
CP001663 Genomic DNA Translation: AFP37293.1
RefSeqiWP_011727226.1, NZ_CP009494.1
YP_885236.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK72853; ABK72853; MSMEG_0832
AFP37293; AFP37293; MSMEI_0813
GeneIDi4534679
KEGGimsb:LJ00_04140
msg:MSMEI_0813
msm:MSMEG_0832
PATRICifig|246196.19.peg.825

Similar proteinsi

Entry informationi

Entry nameiDEF_MYCS2
AccessioniPrimary (citable) accession number: A0QQP8
Secondary accession number(s): I7FEH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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