A0QQ98 (DCD_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	MSMEG_0678

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_1000009759

Sequences

	Sequence		Length	Mass (Da)
	A0QQ98 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 0628F330C155A40A	FASTA	189	20,639
	10 20 30 40 50 60 MLLSDRDIRA EIAAKRLALE PFDDALVQPS SIDVRLDRMF RVFNNTRYTH IDPAMQQDEL 70 80 90 100 110 120 TTLVEPAEGE PFVLHPGEFV LGSTLELCTL PDDLAGRLEG KSSLGRLGLL THSTAGFIDP 130 140 150 160 170 180 GFSGHITLEL SNVANLPITL WPGMKIGQLC LLRLTSPAEN PYGSAAVGSK YQGQRGPTPS RSHLNFIKS

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.
[2]	"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed: 18955433] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], IDENTIFICATION OF N-TERMINUS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK71968.1.
RefSeq	YP_885086.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0QQ98.
SMR	A0QQ98. Positions 1-189.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QQ98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000042044; EBMYCP00000040381; EBMYCG00000042039.
GeneID	4535809.
GenomeReviews	Gene locus MSMEG_0678 in contig CP000480_GR.
KEGG	msm:MSMEG_0678.
NMPDR	fig|246196.1.peg.670.
PATRIC	18073826. VBIMycSme59918_0674.
TIGR	MSMEG_0678.
Phylogenomic databases
eggNOG	COG0717.
GeneTree	EBGT00050000016475.
HOGENOM	HBG553199.
OMA	HTAAYID.
PhylomeDB	A0QQ98.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_0678-MONOMER.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
KO	K01494.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_MYCS2

Accession

Primary (citable) accession number: A0QQ98

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program