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Protein

Phosphate-import permease protein PhnE

Gene

phnE

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPhosphate transport, Transport

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-653-MONOMER

Protein family/group databases

TCDBi3.A.1.9.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate-import permease protein PhnE
Gene namesi
Name:phnE
Ordered Locus Names:MSMEG_0646, MSMEI_0630
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 45HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei85 – 107HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei134 – 156HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei187 – 209HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei216 – 235HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei245 – 267HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei287 – 304HelicalPROSITE-ProRule annotationAdd BLAST18
Transmembranei345 – 367HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei395 – 417HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei452 – 471HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei478 – 495HelicalPROSITE-ProRule annotationAdd BLAST18
Transmembranei505 – 527HelicalPROSITE-ProRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003574691 – 532Phosphate-import permease protein PhnEAdd BLAST532

Expressioni

Inductioni

By phosphate-limited conditions, via derepression by PhnF, and probably also via the two-component regulatory system senX3/regX3.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_0646

Structurei

3D structure databases

ProteinModelPortaliA0QQ68
SMRiA0QQ68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 264ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST184
Domaini341 – 524ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105S7S Bacteria
COG3639 LUCA
HOGENOMiHOG000224624
KOiK02042
OMAiYRFECAL
OrthoDBiPOG091H0H6W

Family and domain databases

CDDicd06261 TM_PBP2, 2 hits
Gene3Di1.10.3720.10, 2 hits
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
IPR005769 PhnE/PtxC
PfamiView protein in Pfam
PF00528 BPD_transp_1, 2 hits
SUPFAMiSSF161098 SSF161098, 2 hits
TIGRFAMsiTIGR01097 PhnE, 2 hits
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 2 hits

Sequencei

Sequence statusi: Complete.

A0QQ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEITRPPA PPSRPSESRK PSLPGLLHLV AIAAVLATIV SAWAIDFVPT
60 70 80 90 100
ALIDGSDNIV ALLQRMIPPR LDDPARIGML AVETLLMAVL GTTLAAIASV
110 120 130 140 150
PLAFLAARNT TPHPAVQAVA RAVITFCRAM PDLLFAVLFV RALGIGVLPG
160 170 180 190 200
VLALALHSIG MLGKVFADAI EQTDAGPREA VRSTGVGYFR ELLNAVVPQV
210 220 230 240 250
VPSWIAMFVY RIDINLRMSV VLGFVGAGGI GFALQDALRG LIYPRALGIV
260 270 280 290 300
CVILVIIAGM ELLAIAIRRI LLDPSRSNPL RDRIARFGLS GVLVGSCVAA
310 320 330 340 350
FVLLKINPLA LFTWVFPSVG IFTRMVPPNF DALGVDLFTA AAQTVAIGVV
360 370 380 390 400
ATAIGIALSI PAGILAARNV SPHPALYWPA RAWILVVRAV PELILAVVFV
410 420 430 440 450
AALGLGPIAG TCALAIGSIG FLAKLVADAV EEIDPGPMEA VRSVGGGWWK
460 470 480 490 500
TLFAAVLPQS MPALVGSSLY LFDVNVRTST ILGIVGAGGV GYLLFESIRT
510 520 530
LNFDVAGAIV IVIFVIVYAI ERLSGWIRSR LV
Length:532
Mass (Da):55,928
Last modified:January 9, 2007 - v1
Checksum:i411F7E36201A62A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK75678.1
CP001663 Genomic DNA Translation: AFP37111.1
RefSeqiWP_011727091.1, NZ_CP009494.1
YP_885056.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK75678; ABK75678; MSMEG_0646
AFP37111; AFP37111; MSMEI_0630
GeneIDi4532128
KEGGimsb:LJ00_03210
msg:MSMEI_0630
msm:MSMEG_0646
PATRICifig|246196.19.peg.642

Similar proteinsi

Entry informationi

Entry nameiPHNE_MYCS2
AccessioniPrimary (citable) accession number: A0QQ68
Secondary accession number(s): I7G248
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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