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Protein

Phosphate-import permease protein PhnE

Gene

phnE

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phosphate transport, Transport

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-646-MONOMER.

Protein family/group databases

TCDBi3.A.1.9.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate-import permease protein PhnE
Gene namesi
Name:phnE
Ordered Locus Names:MSMEG_0646, MSMEI_0630
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4523HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei85 – 10723HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei134 – 15623HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei187 – 20923HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei216 – 23520HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei245 – 26723HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei287 – 30418HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei345 – 36723HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei395 – 41723HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei452 – 47120HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei478 – 49518HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei505 – 52723HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Phosphate-import permease protein PhnEPRO_0000357469Add
BLAST

Expressioni

Inductioni

By phosphate-limited conditions, via derepression by PhnF, and probably also via the two-component regulatory system senX3/regX3.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_0646.

Structurei

3D structure databases

ProteinModelPortaliA0QQ68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 264184ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini341 – 524184ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105S7S. Bacteria.
COG3639. LUCA.
HOGENOMiHOG000224624.
KOiK02042.
OMAiYRFECAL.
OrthoDBiPOG091H0H6W.

Family and domain databases

CDDicd06261. TM_PBP2. 2 hits.
Gene3Di1.10.3720.10. 2 hits.
InterProiIPR000515. MetI-like.
IPR005769. PhnE/PtxC.
[Graphical view]
PfamiPF00528. BPD_transp_1. 2 hits.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 2 hits.
TIGRFAMsiTIGR01097. PhnE. 2 hits.
PROSITEiPS50928. ABC_TM1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QQ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEITRPPA PPSRPSESRK PSLPGLLHLV AIAAVLATIV SAWAIDFVPT
60 70 80 90 100
ALIDGSDNIV ALLQRMIPPR LDDPARIGML AVETLLMAVL GTTLAAIASV
110 120 130 140 150
PLAFLAARNT TPHPAVQAVA RAVITFCRAM PDLLFAVLFV RALGIGVLPG
160 170 180 190 200
VLALALHSIG MLGKVFADAI EQTDAGPREA VRSTGVGYFR ELLNAVVPQV
210 220 230 240 250
VPSWIAMFVY RIDINLRMSV VLGFVGAGGI GFALQDALRG LIYPRALGIV
260 270 280 290 300
CVILVIIAGM ELLAIAIRRI LLDPSRSNPL RDRIARFGLS GVLVGSCVAA
310 320 330 340 350
FVLLKINPLA LFTWVFPSVG IFTRMVPPNF DALGVDLFTA AAQTVAIGVV
360 370 380 390 400
ATAIGIALSI PAGILAARNV SPHPALYWPA RAWILVVRAV PELILAVVFV
410 420 430 440 450
AALGLGPIAG TCALAIGSIG FLAKLVADAV EEIDPGPMEA VRSVGGGWWK
460 470 480 490 500
TLFAAVLPQS MPALVGSSLY LFDVNVRTST ILGIVGAGGV GYLLFESIRT
510 520 530
LNFDVAGAIV IVIFVIVYAI ERLSGWIRSR LV
Length:532
Mass (Da):55,928
Last modified:January 9, 2007 - v1
Checksum:i411F7E36201A62A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75678.1.
CP001663 Genomic DNA. Translation: AFP37111.1.
RefSeqiWP_011727091.1. NZ_CP009494.1.
YP_885056.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75678; ABK75678; MSMEG_0646.
AFP37111; AFP37111; MSMEI_0630.
GeneIDi4532128.
KEGGimsb:LJ00_03210.
msg:MSMEI_0630.
msm:MSMEG_0646.
PATRICi18073760. VBIMycSme59918_0642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75678.1.
CP001663 Genomic DNA. Translation: AFP37111.1.
RefSeqiWP_011727091.1. NZ_CP009494.1.
YP_885056.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QQ68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_0646.

Protein family/group databases

TCDBi3.A.1.9.2. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK75678; ABK75678; MSMEG_0646.
AFP37111; AFP37111; MSMEI_0630.
GeneIDi4532128.
KEGGimsb:LJ00_03210.
msg:MSMEI_0630.
msm:MSMEG_0646.
PATRICi18073760. VBIMycSme59918_0642.

Phylogenomic databases

eggNOGiENOG4105S7S. Bacteria.
COG3639. LUCA.
HOGENOMiHOG000224624.
KOiK02042.
OMAiYRFECAL.
OrthoDBiPOG091H0H6W.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-646-MONOMER.

Family and domain databases

CDDicd06261. TM_PBP2. 2 hits.
Gene3Di1.10.3720.10. 2 hits.
InterProiIPR000515. MetI-like.
IPR005769. PhnE/PtxC.
[Graphical view]
PfamiPF00528. BPD_transp_1. 2 hits.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 2 hits.
TIGRFAMsiTIGR01097. PhnE. 2 hits.
PROSITEiPS50928. ABC_TM1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHNE_MYCS2
AccessioniPrimary (citable) accession number: A0QQ68
Secondary accession number(s): I7G248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.